ArticleThe Journal of physiology2004
Nitric oxide, cAMP and the biphasic muscarinic modulation of ACh release at the lizard neuromuscular junction.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Microelectrode-based approaches for studying cholinergic neuromuscular transmission.Biophysical reviews · 2025Review
- Frequency-Dependent Mechanism of 24-Hydroxycholesterol-Mediated Modulation of Neurotransmitter Release at the Mouse Neuromuscular Junction: The Role of Reactive Oxygen Species.Neurochemical research · 2025Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- Modulation of synaptic vesicle exocytosis in muscle-dependent long-term depression at the amphibian neuromuscular junction.PloS one · 2014Article
- Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction.The Journal of physiology · 2013Article
- Skeletal muscle calpain acts through nitric oxide and neural miRNAs to regulate acetylcholine release in motor nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction.The European journal of neuroscience · 2013Article
- Concepts of neural nitric oxide-mediated transmission.The European journal of neuroscience · 2008Review
- Role of nitric oxide in classical conditioning of siphon withdrawal in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.The European journal of neuroscience · 2007Article
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3 authors.
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Abstract
In this study, we characterized the pharmacology and physiology of the automodulation of ACh release at the lizard neuromuscular junction (NMJ). The activation of muscarinic ACh receptors generated a biphasic modulation of synaptic transmission. Muscarine-induced activation of M3 receptors (0-12 min) decreased release, whereas M1 activation (> 12 min) enhanced release. Both phases of the biphasic effect are dependent on nitric oxide. However, cAMP acting via protein kinase A is also necessary for the M1 effect. In summary, we present a novel biphasic role for muscarine and implicate M3 receptors in the inhibition and M1 receptors in the enhancement of transmitter releaseat the cholinergic lizard NMJ.
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