ArticleEuropean journal of epidemiology2004
Serum fructosamine and colorectal adenomas.
Article in European journal of epidemiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Type 2 diabetes mellitus and risk of colorectal adenoma: a meta-analysis of observational studies.BMC cancer · 2016Pooled it
- Blood Lipid Concentrations and Colorectal Adenomas: A Systematic Review and Meta-Analysis of Colonoscopy Studies in Asia, 2000-2014.American journal of epidemiology · 2016Pooled it
- Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness.Scientific reports · 2025Article
- Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.iScience · 2024Article
- Comprehensive transcriptome analysis of colorectal cancer risk of hyperglycemia in humans.Journal of gastrointestinal oncology · 2021Article
- Review
- Elevated serum triglyceride predicts recurrence of colorectal polyps in patients with advanced adenomas.Lipids in health and disease · 2020Article
- Clinical and Prognostic Relevance of B7-H3 and Indicators of Glucose Metabolism in Colorectal Cancer.Frontiers in oncology · 2020Article
- Diabetes-induced mechanophysiological changes in the small intestine and colon.World journal of diabetes · 2017Review
- Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies.Yonsei medical journal · 2017Article
- Associations Between Parameters of Glucose and Lipid Metabolism and Risk of Colorectal Neoplasm.Digestive diseases and sciences · 2015Article
- Alleviation of Dimethylnitrosamine-Induced Liver Injury and Fibrosis by Supplementation of Anabasis articulata Extract in Rats.Indian journal of clinical biochemistry : IJCB · 2014Article
- Article
- Insulin, insulin-like growth factor 1 and insulin-like growth factor binding protein 3 serum concentrations in patients with adenomatous colon polyps.Przeglad gastroenterologiczny · 2013Article
- Diabetes and risk of cancer.ISRN oncology · 2013Article
- Applying multilevel model to the relationship of dietary patterns and colorectal cancer: an ongoing case-control study in Córdoba, Argentina.European journal of nutrition · 2012Article
- Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients.Cancer cell international · 2011Article
- Low red blood cell levels of deglycating enzymes in colorectal cancer patients.World journal of gastroenterology · 2011Article
- Lack of association between insulin sensitivity and colorectal adenoma risk.Nutrition and cancer · 2011Article
- Reduced fructosamine-3-kinase activity and its mRNA in human distal colorectal carcinoma.Genes & nutrition · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship of glucose in the blood with colorectal adenoma or cancer is not clear. Fructosamine, equivalent to total serum glycated proteins, is a marker of blood glucose levels in the previous 3 weeks. We evaluated in a case-control study the association between fructosamine and colorectal adenoma, a precursor of colorectal cancer. Cases were subjects with the first occurrence of one or more histologically confirmed colorectal adenomatous polyps removed after a complete colonoscopy (153 cases), and controls were subjects with normal colonoscopy performed in the same endoscopy units during the same period (84 controls). Serum fructosamine was measured by a colorimetric method. Unconditional multiple logistic regression was used for statistical analysis. We found that in non-diabetic subjects the risk of colorectal adenoma increased with the level of fructosamine, and the odds ratio of colorectal adenoma in subjects with fructosamine levels higher than the median (270 microg/100 ml), in comparison with subjects with fructosamine lower than the median, was 2.3 (95% CI: 1.1-4.8). The risk of colorectal adenoma increased also with increasing levels of serum triglycerides and cholesterol, and decreased with increasing levels of fasting serum insulin. The results of this study show that the risk of colorectal adenoma increases with the level of fructosamine, an indicator of the level of glucose in the blood more sensitive to foods with a high glycemic index.
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