ArticleHuman genetics2004
Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus.Genes and immunity · 2006Pooled it
- Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis.Human genetics · 2005Pooled it
- Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population.Rheumatology international · 2017Article
- Association Study of a Proliferation-inducing Ligand, Spermatogenesis Associated 8, Platelet-derived Growth Factor Receptor-alpha, and POLB Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population.Chinese medical journal · 2016Article
- Six decades of vitiligo genetics: genome-wide studies provide insights into autoimmune pathogenesis.The Journal of investigative dermatology · 2012Review
- Recent progress in the genetics of generalized vitiligo.Journal of genetics and genomics = Yi chuan xue bao · 2011Review
- Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population.Arthritis research & therapy · 2011Article
- Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease.Thyroid : official journal of the American Thyroid Association · 2010Review
- European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.Arthritis and rheumatism · 2009Article
- Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- CCL genes in multiple sclerosis and systemic lupus erythematosus.Journal of neuroimmunology · 2008Article
- Contribution of genetic studies in rodent models of autoimmune arthritis to understanding and treatment of rheumatoid arthritis.Genes and immunity · 2007Review
- Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans.Human genetics · 2007Article
- Unraveling the genetics of systemic lupus erythematosus.Springer seminars in immunopathology · 2006Review
- Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
23 authors at 15 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies against intracellular components, the formation of immune complexes, and inflammation in various organs, typically the skin and kidney glomeruli. The etiology of the disease is not well understood but is most likely the result of the interaction between genetic and environmental factors. In order to identify susceptibility loci for SLE, we have performed genome scans with microsatellite markers covering the whole genome in families from Argentina, Italy, and Europe. The results reveal a heterogeneous disease with different susceptibility loci in different family sets. We have found significant linkage to chromosome 17p12-q11 in the Argentine set of families. The maximum LOD score was given by marker D17S1294 in combination with D17S1293, when assuming a dominant inheritance model (Z = 3.88). We also analyzed a repeat in the promoter region of the NOS2A gene, a strong candidate gene in the region, but no association was found. The locus on chromosome 17 has previously been identified in genetic studies of multiple sclerosis families. Several other interesting regions were found at 1p35, 1q31, 3q26, 5p15, 11q23 and 19q13, confirming previously identified loci for SLE or other autoimmune diseases.
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