ReviewThe Journal of clinical investigation2004
A noninflammatory pathway for pregnancy loss: innate immune activation?
Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunotherapy for recurrent miscarriage.The Cochrane database of systematic reviews · 2014Pooled it
- A nomogram based on hematological parameters for prediction of spontaneous abortion risk in pregnancies.BMC pregnancy and childbirth · 2025Article
- Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Risk of miscarriage among users of corticosteroid hormones: a population-based nested case-control study.Clinical epidemiology · 2013Article
- Immunopharmacology of ulipristal as an emergency contraceptive.International journal of women's health · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Although the mechanisms of immune-mediated pregnancy loss are unknown, investigations are currently focused on mediators of immune activation and tissue injury at the maternal-fetal interface. A new study, however, demonstrates that systemic inflammatory mediators can induce pregnancy failure in a different way, by inhibiting ovarian hormone production, and identifies links between the immune and reproductive endocrine systems.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.