ArticleJournal of bacteriology2004
The Vibrio cholerae FlgM homologue is an anti-sigma28 factor that is secreted through the sheathed polar flagellum.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Article
- Human antibody targetingmBio · 2025Article
- Interplay of two small RNAs fine-tunes hierarchical flagella gene expression in Campylobacter jejuni.Nature communications · 2024Article
- The cAMP Receptor Protein (CRP) ofAnimals : an open access journal from MDPI · 2024Article
- Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae.PLoS pathogens · 2023Article
- The Vibrio Polar Flagellum: Structure and Regulation.Advances in experimental medicine and biology · 2023Article
- The Polar Flagellar Transcriptional Regulatory Network inJournal of bacteriology · 2021Article
- Sensing of intracellular Hcp levels controls T6SS expression inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Motility of Vibrio spp.: regulation and controlling strategies.Applied microbiology and biotechnology · 2020Review
- c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae.PLoS genetics · 2020Article
- Inefficient Secretion of Anti-sigma Factor FlgM Inhibits Bacterial Motility at High Temperature.iScience · 2019Article
- Review
- Regulated Proteolysis inFrontiers in cellular and infection microbiology · 2019Review
- Silence is golden: gene silencing of V. cholerae during intestinal colonization delivers new aspects to the acid tolerance response.Gut microbes · 2019Article
- A Critical Region in the FlaA Flagellin Facilitates Filament Formation of the Vibrio cholerae Flagellum.Journal of bacteriology · 2018Article
- Functional Analysis of the Alternative Sigma-28 Factor FliA and Its Anti-Sigma Factor FlgM of the Nonflagellated Legionella Species L. oakridgensis.Journal of bacteriology · 2017Article
- Themes and Variations: Regulation of RpoN-Dependent Flagellar Genes across Diverse Bacterial Species.Scientifica · 2014Review
- The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigD.Journal of bacteriology · 2013Article
- FlgM proteins from different bacteria exhibit different structural characteristics.Biochimica et biophysica acta · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
Vibrio cholerae has a single polar sheathed flagellum that propels the cells of this bacterium. Flagellar synthesis, motility, and chemotaxis have all been linked to virulence in this human pathogen. V. cholerae expresses flagellar genes in a hierarchy consisting of sigma54- and sigma28-dependent transcription. In other bacteria, sigma28 transcriptional activity is controlled by an anti-sigma28 factor, FlgM. We demonstrate that the V. cholerae FlgM homologue (i) physically interacts with sigma28, (ii) has a repressive effect on some V. cholerae sigma28-dependent flagellar promoters, and (iii) is secreted through the polar sheathed flagellum, consistent with anti-sigma28 activity. Interestingly, FlgM does not have a uniform repressive effect on all sigma28-dependent promoters, as determined by measurement of sigma28-dependent transcription in cells either lacking FlgM (DeltaflgM) or incapable of secretion (DeltafliF). Further analysis of a DeltafliF strain revealed that this flagellar assembly block causes a decrease in class III (FlrC- and sigma54-dependent) and class IV (sigma28-dependent), but not class II (FlrA- and sigma54-dependent), flagellar transcription. V. cholerae flgM and fliA (encodes sigma28) mutants were only modestly affected in their ability to colonize the infant mouse intestine, a measure of virulence. Our results demonstrate that V. cholerae FlgM functions as an anti-sigma28 factor and that the sheathed flagellum is competent for secretion of nonstructural proteins.
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