ArticleJournal of bacteriology2004
Genes regulated by TorR, the trimethylamine oxide response regulator of Shewanella oneidensis.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Metal Messengers: Communication in the Bacterial World through Transition-Metal-Sensing Two-Component Systems.Biochemistry · 2023Review
- Cross-utilization of β-galactosides and cellobiose inThe Journal of biological chemistry · 2020Article
- Shewanella decolorationis LDS1 Chromate Resistance.Applied and environmental microbiology · 2019Article
- Dissociation between Iron and Heme Biosyntheses Is Largely Accountable for Respiration Defects ofApplied and environmental microbiology · 2018Article
- High Hydrostatic Pressure Inducible TrimethylamineFrontiers in microbiology · 2017Article
- Genomic and physiological analysis reveals versatile metabolic capacity of deep-sea Photobacterium phosphoreum ANT-2200.Extremophiles : life under extreme conditions · 2016Article
- Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Combined genomics and experimental analyses of respiratory characteristics of Shewanella putrefaciens W3-18-1.Applied and environmental microbiology · 2013Article
- Activation of cholera toxin production by anaerobic respiration of trimethylamine N-oxide in Vibrio cholerae.The Journal of biological chemistry · 2012Article
- Article
- Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus.BMC genomics · 2011Article
- The L-Arabinan utilization system of Geobacillus stearothermophilus.Journal of bacteriology · 2011Article
- ArcB1, a homolog of Escherichia coli ArcB, regulates dimethyl sulfoxide reduction in Shewanella oneidensis MR-1.Journal of bacteriology · 2010Article
- Genetic analysis of trimethylamine N-oxide reductases in the light organ symbiont Vibrio fischeri ES114.Journal of bacteriology · 2008Article
- Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses.BMC genomics · 2008Article
- Hierarchical classification of functionally equivalent genes in prokaryotes.Nucleic acids research · 2007Article
- Global transcriptome analysis of Shewanella oneidensis MR-1 exposed to different terminal electron acceptors.Journal of bacteriology · 2005Article
- An internal reference technique for accurately quantifying specific mRNAs by real-time PCR with application to the tceA reductive dehalogenase gene.Applied and environmental microbiology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The torECAD operon encoding the trimethylamine oxide (TMAO) respiratory system of Shewanella oneidensis is positively controlled by the TorS/TorR two-component system when TMAO is available. Activation of the tor operon occurs upon binding of the phosphorylated response regulator TorR to a single operator site containing the direct repeat nucleotide sequence TTCATAN4TTCATA. Here we show that the replacement of any nucleotide of one TTCATA hexamer prevented TorR binding in vitro, meaning that TorR specifically interacts with this DNA target. Identical direct repeat sequences were found in the promoter regions of torR and of the new gene torF (SO4694), and they allowed TorR binding to both promoters. Real-time PCR experiments revealed that torR is negatively autoregulated, whereas torF is strongly induced by TorR in response to TMAO. Transcription start site location and footprinting analysis indicate that the operator site at torR overlaps the promoter -10 box, whereas the operator site at torF is centered at -74 bp from the start site, in agreement with the opposite role of TorR in the regulation of the two genes. Since torF and torECAD are positively coregulated by TorR, we propose that the TorF protein plays a role related to TMAO respiration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.