ArticleGenome research2004
A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 145 citations in OpenAlex.
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- Detection of genetic association and functional polymorphisms of UGDH affecting milk production trait in Chinese Holstein cattle.BMC genomics · 2012Article
- A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb.BMC genomics · 2012Article
- Association of five candidate genes with fatty acid composition in Korean cattle.Molecular biology reports · 2012Article
- Advanced comparative cytogenetic analysis of X chromosomes in river buffalo, cattle, sheep, and human.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Ancestral grass karyotype reconstruction unravels new mechanisms of genome shuffling as a source of plant evolution.Genome research · 2010Article
- A complete DNA sequence map of the ovine major histocompatibility complex.BMC genomics · 2010Article
- Comparative genomics reveals birth and death of fragile regions in mammalian evolution.Genome biology · 2010Article
- FISH mapping in cattle (Bos taurus L.) is not yet out of fashion.Journal of applied genetics · 2010Article
- Database of cattle candidate genes and genetic markers for milk production and mastitis.Animal genetics · 2009Article
- Every genome sequence needs a good map.Genome research · 2009Article
- Breakpoint graphs and ancestral genome reconstructions.Genome research · 2009Article
- Breakpoint regions and homologous synteny blocks in chromosomes have different evolutionary histories.Genome research · 2009Article
- A high density linkage map of the bovine genome.BMC genetics · 2009Article
- Application of dissociation curve analysis to radiation hybrid panel marker scoring: generation of a map of river buffalo (B. bubalis) chromosome 20.BMC genomics · 2008Article
- Centromere repositioning in the X chromosome of XO/XO mammals, Ryukyu spiny rat.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- A 4,103 marker integrated physical and comparative map of the horse genome.Cytogenetic and genome research · 2008Article
- Are there rearrangement hotspots in the human genome?PLoS computational biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A second-generation 5000 rad radiation hybrid (RH) map of the cattle genome was constructed primarily using cattle ESTs that were targeted to gaps in the existing cattle-human comparative map, as well as to sparsely populated map intervals. A total of 870 targeted markers were added, bringing the number of markers mapped on the RH(5000) panel to 1913. Of these, 1463 have significant BLASTN hits (E < e(-5)) against the human genome sequence. A cattle-human comparative map was created using human genome sequence coordinates of the paired orthologs. One-hundred and ninety-five conserved segments (defined by two or more genes) were identified between the cattle and human genomes, of which 31 are newly discovered and 34 were extended singletons on the first-generation map. The new map represents an improvement of 20% genome-wide comparative coverage compared with the first-generation map. Analysis of gene content within human genome regions where there are gaps in the comparative map revealed gaps with both significantly greater and significantly lower gene content. The new, more detailed cattle-human comparative map provides an improved resource for the analysis of mammalian chromosome evolution, the identification of candidate genes for economically important traits, and for proper alignment of sequence contigs on cattle chromosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.