ArticleGenome research2004
Global survey of chromatin accessibility using DNA microarrays.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Patterns in the genome.Heredity · 2019Review
- Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes.Molecular cytogenetics · 2015Article
- Measuring Arabidopsis chromatin accessibility using DNase I-polymerase chain reaction and DNase I-chip assays.Plant physiology · 2013Article
- Distinct modes of DNA accessibility in plant chromatin.Nature communications · 2012Article
- Chromatin remodeling in mammary gland differentiation and breast tumorigenesis.Cold Spring Harbor perspectives in biology · 2010Review
- Genome-wide profiling of salt fractions maps physical properties of chromatin.Genome research · 2009Article
- Genome-wide approaches to studying chromatin modifications.Nature reviews. Genetics · 2008Review
- Maps of cis-Regulatory Nodes in Megabase Long Genome Segments are an Inevitable Intermediate Step Toward Whole Genome Functional Mapping.Current genomics · 2007Article
- Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatin.Genome research · 2006Article
- Applying whole-genome studies of epigenetic regulation to study human disease.Cytogenetic and genome research · 2006Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
An increasing number of studies indicate a central role for chromatin remodeling in the regulation of gene expression. Current methods for high-resolution studies of the relationship between chromatin accessibility and transcription are low throughput, making a genome-wide study impractical. To enable the simultaneous measurement of the global chromatin accessibility state at the resolution of single genes, we developed the Chromatin Array technique, in which chromatin is separated by its condensation state using either the solubility differences of mono- and oligonucleosomes in specific buffers or controlled DNase I digestion and selection of the large refractory (condensed) DNA fragments. By probing with a comparative genomic hybridization style microarray, we can determine the condensation state of thousands of individual loci and correlate this with transcriptional activity. Applying this technique to the breast tumor model cell line, MCF7, we found that when the condensation is homogeneous in the population of cells, expression is inversely proportional to the level of accessibility and the two methods of accessibility-based target selection correlate well. Using functional annotation and comparative genomic hybridization data, we have begun to decipher the possible biological implications of the relationship between chromatin accessibility and expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.