ArticleGenome research2004
Recovery of a function involving gene duplication by retroposition in Saccharomyces cerevisiae.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- The genetics of the many forms of diversity.Genetics · 2026Article
- Nuku, a family of primate retrocopies derived from KU70.G3 (Bethesda, Md.) · 2021Article
- Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective.Mobile DNA · 2020Review
- LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans.Genome research · 2016Article
- Pseudogenes and Their Genome-Wide Prediction in Plants.International journal of molecular sciences · 2016Review
- The Ty1 LTR-retrotransposon of budding yeast,Microbiology spectrum · 2015Article
- Go retro and get a GRIP.Genome biology · 2013Article
- Retrotransposition of gene transcripts leads to structural variation in mammalian genomes.Genome biology · 2013Article
- Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae.BMC genomics · 2011Article
- Yeast evolutionary genomics.Nature reviews. Genetics · 2010Review
- Origin and fate of pseudogenes in Hemiascomycetes: a comparative analysis.BMC genomics · 2010Article
- Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae.Genetics · 2010Article
- Genome-wide computational prediction of tandem gene arrays: application in yeasts.BMC genomics · 2010Article
- Fusion and retrotransposition events in the evolution of the sea anemone Anemonia viridis neurotoxin genes.Journal of molecular evolution · 2009Article
- Influence of genetic background on the occurrence of chromosomal rearrangements in Saccharomyces cerevisiae.BMC genomics · 2009Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Fusion and fission of genes define a metric between fungal genomes.PLoS computational biology · 2008Article
- Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants.Genetics · 2008Article
- Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis.Journal of molecular evolution · 2008Article
- Retrosequence formation restructures the yeast genome.Genes & development · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The duplication of DNA sequences contributes to genomic plasticity and is known to be one of the key factors responsible for evolution. The mechanisms underlying these rare events, which have been frequently mentioned by authors performing genomic analysis, have not yet been completely elucidated. These mechanisms were approached here in the yeast Saccharomyces cerevisiae, using a positive selection screen based on a particular mutated allele of the URA2 gene. Spontaneous revertants containing a duplication of the terminal part of the URA2 gene were selected and analyzed. Some important features of the duplicated regions, such as their chromosome location, size, and insertion sites, were characterized. The events selected correspond to a single inter- or intrachromosomal gene duplication process. The duplicated ATCase sequence is generally punctuated by a poly(A) tract and is always located in Ty1 sequences. In addition, the activation of a Ty1 transcription process increased the frequency of the duplication events. All in all, these data suggest that the duplication mechanism involves the reverse transcription of mRNA and the subsequent integration of the cDNA into a Ty1 area. The Ty1 elements and the retrotransposon-encoded function are key factors contributing to chromosomal reshaping. The genomic rearrangements described constitute experimental evidence for the recovery of a function involving duplication by retroposition.
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