ReviewEMBO reports2004
The replicon revisited: an old model learns new tricks in metazoan chromosomes.
Review in EMBO reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.Nature communications · 2020Article
- Origins of DNA replication.PLoS genetics · 2019Review
- 3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression.Nature communications · 2016Article
- Article
- The hunt for origins of DNA replication in multicellular eukaryotes.F1000prime reports · 2015Review
- Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins.Genome research · 2013Article
- Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control.Genes & cancer · 2012Article
- Initiation of DNA Replication in the Human Genome.Hereditary genetics : current research · 2012Article
- Genome-wide depletion of replication initiation events in highly transcribed regions.Genome research · 2011Article
- Nucleosomes in the neighborhood: new roles for chromatin modifications in replication origin control.Epigenetics · 2011Review
- Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.Genome research · 2011Article
- Human initiation protein Orc4 prefers triple stranded DNA.Molecular biology reports · 2010Article
- A comprehensive genome-wide map of autonomously replicating sequences in a naive genome.PLoS genetics · 2010Article
- Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.Genome research · 2010Article
- Episomal high copy number maintenance of hairpin-capped DNA bearing a replication initiation region in human cells.The Journal of biological chemistry · 2009Article
- SV40 DNA replication: from the A gene to a nanomachine.Virology · 2009Review
- Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins.The EMBO journal · 2009Article
- A novel 154-bp deletion in the human mitochondrial DNA control region in healthy individuals.Human mutation · 2008Article
- Asymmetric bidirectional replication at the human DBF4 origin.Nature structural & molecular biology · 2008Article
- Tetrahymena ORC contains a ribosomal RNA fragment that participates in rDNA origin recognition.The EMBO journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The origins of DNA replication were proposed in the replicon model to be specified genetically by replicator elements that coordinate the initiation of DNA synthesis with gene expression and cell growth. Recent studies have identified DNA sequences in mammalian cells that fulfil the genetic criteria for replicators and are beginning to uncover the sequence requirements for the initiation of DNA replication. Mammalian replicators are com- posed of non-redundant modules that cooperate to direct initiation to specific chromosomal sites. Conversely, replicators do not show strong sequence similarity, and their ability to initiate replication depends on the chromosomal context and epigenetic factors, as well as their primary sequence. Here, we review the properties of metazoan replicators, and discuss the genetic and epigenetic factors that determine where and when DNA replication is initiated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.