ArticleProceedings of the National Academy of Sciences of the United States of America2004
Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Expression of CD64 (FcγRI) in skin of patients with acute GVHD.Bone marrow transplantation · 2011Trial
- Prognostic implications of PPL expression in ovarian cancer.Discover oncology · 2022Article
- Novel HumanFrontiers in immunology · 2022Article
- The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence.Cell communication and signaling : CCS · 2021Review
- SUMOylation of periplakin is critical for efficient reorganization of keratin filament network.Molecular biology of the cell · 2019Article
- Inside-Out Control of Fc-Receptors.Frontiers in immunology · 2019Review
- Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI.Science signaling · 2018Article
- Identification of periplakin as a major regulator of lung injury and repair in mice.JCI insight · 2018Article
- Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer.Journal of translational medicine · 2014Review
- Cholestasis induces reversible accumulation of periplakin in mouse liver.BMC gastroenterology · 2013Article
- Cross-presentation of IgG-containing immune complexes.Cellular and molecular life sciences : CMLS · 2013Review
- Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output.Oncogene · 2012Article
- Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.Journal of leukocyte biology · 2012Article
- Fcγ receptor I alpha chain (CD64) expression in macrophages is critical for the onset of meningitis by Escherichia coli K1.PLoS pathogens · 2010Article
- Divergent intracellular sorting of Fc{gamma}RIIA and Fc{gamma}RIIB2.The Journal of biological chemistry · 2010Article
- B-cells get the T-cells but antibodies get the worms.Trends in parasitology · 2009Article
- Fc-receptors and immunity to malaria: from models to vaccines.Parasite immunology · 2009Review
- The importance of human FcgammaRI in mediating protection to malaria.PLoS pathogens · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FcgammaRI depends for its biological function on both the intracellular domain of the alpha-chain and associated Fc receptor (FcR) gamma-chains. However, functional protein effectors of FcgammaRI's intracellular domain have not been identified. In this study, we identified periplakin (PPL) as a selective interacting protein for the intracellular tail of FcgammaRI but no other activatory FcRs. The interaction was confirmed by coimmunoprecipitation and blot-overlay assays. PPL and FcgammaRI colocalized at the plasma membrane in monocytes and cell transfectants, and both were up-regulated by IFN-gamma. By expressing C-terminal PPL in transfectants, we established a pivotal role for this protein in FcgammaRI ligand binding, endocytosis, and antigen presentation. These data illustrate that intracellular protein interactions with a multisubunit FcR alpha-chain can confer unique properties to the receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.