ArticleBritish journal of cancer2004
Measles virus: evidence of an association with Hodgkin's disease.
Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.Blood · 2018Pooled it
- Relevance of the Measles Virus Expression in Cancer - an Update.Pathology oncology research : POR · 2016Review
- Atypical measles syndrome in adults: still around.BMJ case reports · 2015Article
- Does the measles virus contribute to carcinogenesis? - a review.Journal of Cancer · 2014Review
- Article
- A pro-inflammatory role for nuclear factor kappa B in childhood obstructive sleep apnea syndrome.Sleep · 2013Article
- Primary Refractory and Relapsed Classical Hodgkin Lymphoma - Significance of Differential CD15 Expression in Hodgkin-Reed-Sternberg Cells.Journal of Cancer · 2012Article
- High content of Langerhans cells in malignant lymphoma--incidence and significance.Virchows Archiv : an international journal of pathology · 2010Article
- Measles control--can measles virus inhibitors make a difference?Current opinion in investigational drugs (London, England : 2000) · 2009Review
- Ethnicity and incidence of Hodgkin lymphoma in Canadian population.BMC cancer · 2009Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quest for an infectious agent that may account for cases of Hodgkin's disease (HD) especially in young adults has proven vain until lately. We have recently reported findings that suggested the presence of measles virus (MV) antigens and MV RNA in the tissues of patients with HD. Support for an association between MV and HD has been provided by recent epidemiological findings relating the occurrence of HD to exposure to measles in pregnancy and the perinatal period. We now present further evidence of this putative association based on immunohistochemical, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridisation studies (ISH) on HD tissues. Biopsies from 82 (54.3%) of our cohort of 154 patients showed a positive immunostain with at least two of the anti-measles antibodies used. Latent membrane protein-1 immunostaining for Epstein-Barr virus was positive in 46 (31.1%) of the patients examined. Reverse transcriptase-PCR and ISH for measles RNA were positive in seven and 10 of 28 patients, respectively. Preliminary clinicopathological associations between MV and HD are noted in this study, but no causal relationship can be claimed at this stage.
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