Evidence map›Paper›PMID 15226773›Full record

Trial reportBritish journal of cancer2004

Nutrition intervention is beneficial in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area.

E A Isenring, S Capra, J D Bauer

3 registry-linked trialsOpen access · hybridAbstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 136 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 15 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03100409 naterminatednot on this mapstarted 2017, after this paper: background citation

Effect of a Low Residue Diet in Comparison to the Dietary Recommendations From the INCan: A Randomized Clinical Trial to Assess Malnutrition, Gastrointestinal Toxicity and Quality of Life of Advanced Cervical Cancer Patients (IB2-IVA)

TypeinterventionalSponsorNational Institute of CancerologíaRan2017 to 2021Enrolled137ConditionsUterine Cervical Neoplasm, Dietary Modification, Radiation Toxicity, Gastrointestinal ComplicationArmsDietary modification
NCT03673657 phase2completednot on this mapstarted 2018, after this paper: background citation

A Prospective, Single-arm, Phase II Study of Early Nutritional Intervention During Concurrent Chemoradiotherapy for Local Advanced Non-small Cell Lung Cancer

TypeinterventionalSponsorSun Yat-sen UniversityRan2018 to 2023Enrolled67ConditionsLocal Advanced Non-small Cell Lung CancerArmsEarly Nutrition Intervention from the start of CCRT, Thoracic radiotherapy, Weekly DP chemotherapy concurrent with thoracic radiotherapy
NCT04155008 phase4terminatednot on this mapstarted 2021, after this paper: background citation

Assessing Quality of Life and the Feasibility of a Nutrition and Pharmacological Algorithm for Oncology Patients With Anorexia

TypeinterventionalSponsorMontefiore Medical CenterRan2021 to 2021Enrolled1ConditionsOncologic Complications, Quality of Life, Nutrition Poor, Head and Neck CancerArmsDexamethasone, Dronabinol, Mirtazapine, Nutrition Intervention
3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 15 syntheses or guidelines pooled it, 489 citations in OpenAlex.

  1. The effect of blended tube feeding compared to conventional formula on clinical outcomes in adults: A systematic review.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2026
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  6. Impact of nutrition counseling on nutrition status in patients with head and neck cancer undergoing radio- or radiochemotherapy: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
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  9. Nutritional prehabilitation in head and neck cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  12. Intensive nutritional care for patients treated with radiotherapy in head and neck cancer: a randomized study and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Pooled it
  13. Nutrition intervention approaches to reduce malnutrition in oncology patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
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  15. Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010
    Pooled it
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  17. Effect of individualized nutritional intervention on head and neck cancer patients receiving radiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E A IsenringSchool of Public Health, Queensland University of Technology, Brisbane, Australia. e.isenring@qut.edu.au
S Capra
J D Bauer
Queensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malnutrition occurs frequently in patients with cancer of the gastrointestinal (GI) or head and neck area and can lead to negative outcomes. The aim of this study is to determine the impact of early and intensive nutrition intervention (NI) on body weight, body composition, nutritional status, global quality of life (QoL) and physical function compared to usual practice in oncology outpatients receiving radiotherapy to the GI or head and neck area. Outpatients commencing at least 20 fractions of radiotherapy to the GI or head and neck area were randomised to receive intensive, individualised nutrition counselling by a dietitian using a standard protocol and oral supplements if required, or the usual practice of the centre (general advice and nutrition booklet). Outcome parameters were measured at baseline and 4, 8 and 12 weeks after commencing radiotherapy using valid and reliable tools. A total of 60 patients (51 M : 9 F; mean age 61.9+/-14.0 years) were randomised to receive either NI (n=29) or usual care (UC) (n=31). The NI group had statistically smaller deteriorations in weight (P<0.001), nutritional status (P=0.020) and global QoL (P=0.009) compared with those receiving UC. Clinically, but not statistically significant differences in fat-free mass were observed between the groups (P=0.195). Early and intensive NI appears beneficial in terms of minimising weight loss, deterioration in nutritional status, global QoL and physical function in oncology outpatients receiving radiotherapy to the GI or head and neck area. Weight maintenance in this population leads to beneficial outcomes and suggests that this, rather than weight gain, may be a more appropriate aim of NI.

Indexed as

Nutritional SupportAdultAgedBody CompositionBody WeightFemaleGastrointestinal NeoplasmsHead and Neck NeoplasmsHumansMaleMalnutritionMiddle AgedNutritional StatusOutpatientsProspective StudiesQuality of Life

Identifiers

PMID15226773
PMCPMC2409852
OpenAlexW2079633493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.