ArticleProceedings of the National Academy of Sciences of the United States of America2004
Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 78 citations in OpenAlex.
- Evolution of the expression and regulation of the nuclear hormone receptor ERR gene family in the chordate lineage.Developmental biology · 2023Article
- Article
- Highly distinct genetic programs for peripheral nervous system formation in chordates.BMC biology · 2022Article
- A Preliminary Single-Cell RNA-Seq Analysis of Embryonic Cells That ExpressFrontiers in cell and developmental biology · 2021Article
- An Orthologue of the Retinoic Acid Receptor (RAR) Is Present in the Ecdysozoa Phylum Priapulida.Genes · 2019Article
- Retinoic acid signaling and neurogenic niche regulation in the developing peripheral nervous system of the cephalochordate amphioxus.Cellular and molecular life sciences : CMLS · 2018Article
- Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System.Molecular neurobiology · 2018Article
- The structure, splicing, synteny and expression of lamprey COE genes and the evolution of the COE gene family in chordates.Development genes and evolution · 2017Article
- Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles.BMC evolutionary biology · 2017Article
- Developmental Mechanism of Limb Field Specification along the Anterior-Posterior Axis during Vertebrate Evolution.Journal of developmental biology · 2016Review
- Article
- Broken colinearity of the amphioxus Hox cluster.EvoDevo · 2012Article
- Antagonizing retinoic acid and FGF/MAPK pathways control posterior body patterning in the invertebrate chordate Ciona intestinalis.PloS one · 2012Article
- Loss of abdominal muscle in Pitx2 mutants associated with altered axial specification of lateral plate mesoderm.PloS one · 2012Article
- Evolution of invertebrate deuterostomes and Hox/ParaHox genes.Genomics, proteomics & bioinformatics · 2011Review
- Evolution of retinoid and steroid signaling: vertebrate diversification from an amphioxus perspective.Genome biology and evolution · 2011Article
- From carrot to clinic: an overview of the retinoic acid signaling pathway.Cellular and molecular life sciences : CMLS · 2010Review
- The metazoan history of the COE transcription factors. Selection of a variant HLH motif by mandatory inclusion of a duplicated exon in vertebrates.BMC evolutionary biology · 2008Article
- The amphioxus SoxB family: implications for the evolution of vertebrate placodes.International journal of biological sciences · 2007Article
- Expression of AmphiPOU-IV in the developing neural tube and epidermal sensory neural precursors in amphioxus supports a conserved role of class IV POU genes in the sensory cells development.Development genes and evolution · 2006Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In developing chordates, retinoic acid (RA) signaling patterns the rostrocaudal body axis globally and affects gene expression locally in some differentiating cell populations. Here we focus on development of epidermal sensory neurons in an invertebrate chordate (amphioxus) to determine how RA signaling influences their rostrocaudal distribution and gene expression (for AmphiCoe, a neural precursor gene; for amphioxus islet and AmphiERR, two neural differentiation genes; and for AmphiHox1, -3, -4, and -6). Treatments with RA or an RA antagonist (BMS009) shift the distribution of developing epidermal neurons anteriorly or posteriorly, respectively. These treatments also affect gene expression patterns in the epidermal neurons, suggesting that RA levels may influence specification of neuronal subtypes. Although colinear expression of Hox genes is well known for the amphioxus central nervous system, we find an unexpected comparable colinearity for AmphiHox1, -3, -4, and -6 in the developing epidermis; moreover, RA levels affect the anteroposterior extent of these Hox expression domains, suggesting that RA signaling controls a colinear Hox code for anteroposterior patterning of the amphioxus epidermis. Thus, in amphioxus, the developing peripheral nervous system appears to be structured by mechanisms parallel to those that structure the central nervous system. One can speculate that, during evolution, an ancestral deuterostome that structured its panepidermal nervous system with an RA-influenced Hox code gave rise to chordates in which this patterning mechanism persisted within the epidermal elements of the peripheral nervous system and was transferred to the neuroectoderm as the central nervous system condensed dorsally.
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