ArticleMolecular and cellular biology2004
Mcm1 promotes replication initiation by binding specific elements at replication origins.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.Nucleus (Austin, Tex.) · 2023Review
- Sis2 regulates yeast replicative lifespan in a dose-dependent manner.Nature communications · 2023Article
- GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris.PLoS genetics · 2014Article
- Mef2A, a homologue of animal Mef2 transcription factors, regulates cell differentiation in Dictyostelium discoideum.BMC developmental biology · 2013Article
- Transcription-replication encounters, consequences and genomic instability.Nature structural & molecular biology · 2013Review
- Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae.Cell · 2012Article
- Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Identifying functional single nucleotide polymorphisms in the human CArGome.Physiological genomics · 2011Article
- High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements.Nucleic acids research · 2011Article
- Epigenetics in atherosclerosis and inflammation.Journal of cellular and molecular medicine · 2010Review
- Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase.BMC molecular biology · 2008Article
- Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast.BMC bioinformatics · 2008Article
- Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site.Molecular and cellular biology · 2008Article
- Article
- Functional taxonomy of bacterial hyperstructures.Microbiology and molecular biology reviews : MMBR · 2007Review
- Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae.PLoS genetics · 2006Article
- N-terminal arm of Mcm1 is required for transcription of a subset of genes involved in maintenance of the cell wall.Eukaryotic cell · 2005Article
- Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression.Genes & development · 2005Article
- The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Minichromosome maintenance protein 1 (Mcm1) is required for efficient replication of autonomously replicating sequence (ARS)-containing plasmids in yeast cells. Reduced DNA binding activity in the Mcm1-1 mutant protein (P97L) results in selective initiation of a subset of replication origins and causes instability of ARS-containing plasmids. This plasmid instability in the mcm1-1 mutant can be overcome for a subset of ARSs by the inclusion of flanking sequences. Previous work showed that Mcm1 binds sequences flanking the minimal functional domains of ARSs. Here, we dissected two conserved telomeric X ARSs, ARS120 (XARS6L) and ARS131a (XARS7R), that replicate with different efficiencies in the mcm1-1 mutant. We found that additional Mcm1 binding sites in the C domain of ARS120 that are missing in ARS131a are responsible for efficient replication of ARS120 in the mcm1-1 mutant. Mutating a conserved Mcm1 binding site in the C domain diminished replication efficiency in ARS120 in wild-type cells, and increasing the number of Mcm1 binding sites stimulated replication efficiency. Our results suggest that threshold occupancy of Mcm1 in the C domain of telomeric ARSs is required for efficient initiation. We propose that origin usage in Saccharomyces cerevisiae may be regulated by the occupancy of Mcm1 at replication origins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.