ArticleMolecular and cellular biology2004
Periplakin gene targeting reveals a constituent of the cornified cell envelope dispensable for normal mouse development.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Western Diet Induced Remodelling of the Tongue Proteome.Proteomes · 2021Article
- Keratins and the plakin family cytolinker proteins control the length of epithelial microridge protrusions.eLife · 2020Article
- The Role of Caspase-2 in Regulating Cell Fate.Cells · 2020Review
- The Delta-Opioid Receptor; a Target for the Treatment of Pain.Frontiers in molecular neuroscience · 2020Review
- Identification of periplakin as a major regulator of lung injury and repair in mice.JCI insight · 2018Article
- Homeobox transcription factor DLX4 is not necessary for skin development and homeostasis.Experimental dermatology · 2018Article
- PRIMA1 mutation: a new cause of nocturnal frontal lobe epilepsy.Annals of clinical and translational neurology · 2015Article
- Aberrant DNA hypermethylation reduces the expression of the desmosome-related molecule periplakin in esophageal squamous cell carcinoma.Cancer medicine · 2015Article
- Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.eLife · 2014Article
- Epidermal barriers.Cold Spring Harbor perspectives in medicine · 2014Review
- Cholestasis induces reversible accumulation of periplakin in mouse liver.BMC gastroenterology · 2013Article
- Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.Developmental cell · 2012Article
- Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.The Journal of experimental medicine · 2012Article
- CASK (LIN2) interacts with Cx43 in wounded skin and their coexpression affects cell migration.Journal of cell science · 2012Article
- Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.Nature reviews. Molecular cell biology · 2011Review
- The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium.International review of cell and molecular biology · 2011Review
- Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.The Journal of cell biology · 2007Article
- Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia.Molecular and cellular biology · 2006Article
- Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane.The Journal of cell biology · 2004Article
- Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress.Cardiovascular pathology : the official journal of the Society for Cardiovascular PathologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The members of the plakin family of proteins serve as epidermal cytolinkers and components of cell-cell and cell-matrix adhesion complexes, i.e., desmosomes and hemidesmosomes, respectively. Periplakin is a recently characterized member of this family. Human and mouse periplakin genomic loci are conserved, and the proteins are highly homologous, suggesting a role for periplakin in vertebrate physiology. In order to evaluate the functional role of periplakin, we generated periplakin null mice through targeted homologous recombination of mouse embryonic stem cells, followed by development of Ppl(-/-) mice. Mice homozygous for the targeted allele were born in the expected Mendelian frequency, developed normally, possessed grossly normal epidermis and hair, and were healthy and fertile. The epidermal barrier appeared to develop normally during fetal days E15.5 to E16.5, and the cornified envelope and desmosomes in the newborn mice were ultrastructurally normal. No compensatory increase in the expression of other epithelial proteins was detected in the neonatal mouse epidermis lacking periplakin. Consequently, the primary role of periplakin may not relate to the physiology of the cornified cell envelope in epidermal keratinocytes but may reside in the challenges, which normal laboratory mice do not encounter.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.