ArticleMolecular and cellular biology2004
The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases.Cell discovery · 2026Review
- Photoreactivation Activities of Rad5, Rad16A and Rad16B HelpJournal of fungi (Basel, Switzerland) · 2024Article
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- Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer.PLoS genetics · 2022Article
- Nucleosome remodeling at origins of global genome-nucleotide excision repair occurs at the boundaries of higher-order chromatin structure.Genome research · 2019Article
- Regulation of DNA Repair Mechanisms: How the Chromatin Environment Regulates the DNA Damage Response.International journal of molecular sciences · 2017Review
- Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin.Genome research · 2016Article
- Structural Basis for Modulation of Quality Control Fate in a Marginally Stable Protein.Structure (London, England : 1993) · 2015Article
- Maize Elongin C interacts with the viral genome-linked protein, VPg, of Sugarcane mosaic virus and facilitates virus infection.The New phytologist · 2014Article
- Chromatin modifications and DNA repair: beyond double-strand breaks.Frontiers in genetics · 2014Review
- Review
- Article
- A role for SUMO in nucleotide excision repair.DNA repair · 2011Article
- How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae.PLoS genetics · 2011Article
- Cdc48/p97 mediates UV-dependent turnover of RNA Pol II.Molecular cell · 2011Article
- The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair.The Journal of biological chemistry · 2010Article
- Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression.The EMBO journal · 2009Article
- In silico construction of a protein interaction landscape for nucleotide excision repair.Cell biochemistry and biophysics · 2009Article
- Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.The Journal of biological chemistry · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Nucleotide excision repair factor 4 (NEF4) is required for repair of nontranscribed DNA in Saccharomyces cerevisiae. Rad7 and the Snf2/Swi2-related ATPase Rad16 are NEF4 subunits. We report previously unrecognized similarity between Rad7 and F-box proteins. Rad16 contains a RING domain embedded within its ATPase domain, and the presence of these motifs in NEF4 suggested that NEF4 functions as both an ATPase and an E3 ubiquitin ligase. Mutational analysis provides strong support for this model. The Rad16 ATPase is important for NEF4 function in vivo, and genetic analysis uncovered new interactions between NEF4 and Rad23, a repair factor that links repair to proteasome function. Elc1 is the yeast homologue of a mammalian E3 subunit, and it is a novel component of NEF4. Moreover, the E2s Ubc9 and Ubc13 were linked to the NEF4 repair pathway by genetic criteria. Mutations in NEF4 or Ubc13 result in elevated levels of the DNA damage recognition protein Rad4 and an increase in ubiquitylated species of Rad23. As Rad23 also controls Rad4 levels, these results suggest a complex system for globally regulating repair activity in vivo by controlling turnover of Rad4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.