ReviewArthritis research & therapy2004
Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies.
Review in Arthritis research & therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- [Synovialitis score: histopathological grading system for chronic rheumatic and non-rheumatic synovialitis].Zeitschrift fur Rheumatologie · 2005Trial
- Integrated transcriptomic correlation network analysis identifies COPD molecular determinants.Scientific reports · 2020Article
- Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration.Arthritis research & therapy · 2009Article
- Arthritis suppression by NADPH activation operates through an interferon-beta pathway.BMC biology · 2007Article
- [Differential diagnosis of rheumatoid granuloma].Der Pathologe · 2006Article
- [Low-grade-/high-grade-synovitis: synovitis-score as a gold standard?].Der Orthopade · 2006Article
- Safety concerns on the development of novel therapeutic drugs.Arthritis research & therapy · 2006Article
- [Research strategies towards a holistic characterization of rheumatoid arthritis--a systems biology approach].Zeitschrift fur Rheumatologie · 2005Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The deciphering of the sequence of the human genome has raised the expectation of unravelling the specific role of each gene in physiology and pathology. High-throughput technologies for gene expression profiling provide the first practical basis for applying this information. In rheumatology, with its many diseases of unknown pathogenesis and puzzling inflammatory aspects, these advances appear to promise a significant advance towards the identification of leading mechanisms of pathology. Expression patterns reflect the complexity of the molecular processes and are expected to provide the molecular basis for specific diagnosis, therapeutic stratification, long-term monitoring and prognostic evaluation. Identification of the molecular networks will help in the discovery of appropriate drug targets, and permit focusing on the most effective and least toxic compounds. Current limitations in screening technologies, experimental strategies and bioinformatic interpretation will shortly be overcome by the rapid development in this field. However, gene expression profiling, by its nature, will not provide biochemical information on functional activities of proteins and might only in part reflect underlying genetic dysfunction. Genomic and proteomic technologies will therefore be complementary in their scientific and clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.