ArticleJournal of bioenergetics and biomembranes2004
Formation of palmitic acid/Ca2+ complexes in the mitochondrial membrane: a possible role in the cyclosporin-insensitive permeability transition.
Article in Journal of bioenergetics and biomembranes, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- The Short-Term Opening of Cyclosporin A-Independent Palmitate/SrMembranes · 2022Article
- Review
- Membranotropic effects of ω-hydroxypalmitic acid and CaJournal of bioenergetics and biomembranes · 2018Article
- Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies.Bioscience reports · 2015Review
- Effect of surface-potential modulators on the opening of lipid pores in liposomal and mitochondrial inner membranes induced by palmitate and calcium ions.Biochimica et biophysica acta · 2015Article
- Ca(2+)-dependent nonspecific permeability of the inner membrane of liver mitochondria in the guinea fowl (Numida meleagris).Journal of bioenergetics and biomembranes · 2015Article
- A permeability transition in liver mitochondria and liposomes induced by α,ω-dioic acids and Ca(2+).European biophysics journal : EBJ · 2014Article
- Oxidative phosphorylation and ion transport in the mitochondria of two strains of rats varying in their resistance to stress and hypoxia.Molecular and cellular biochemistry · 2013Article
- Palmitic acid induces the opening of a Ca2+-dependent pore in the plasma membrane of red blood cells: the possible role of the pore in erythrocyte lysis.The Journal of membrane biology · 2010Article
- Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia.Journal of bioenergetics and biomembranes · 2009Article
- Mitochondrial Ca2+ cycle mediated by the palmitate-activated cyclosporin A-insensitive pore.Journal of bioenergetics and biomembranes · 2007Article
- Ca2+-induced phase separation in the membrane of palmitate-containing liposomes and its possible relation to membrane permeabilization.The Journal of membrane biology · 2007Article
- On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria.Journal of bioenergetics and biomembranes · 2006Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A possible role of palmitic acid/Ca2+ (PA/Ca2+) complexes in the cyclosporin-insensitive permeability transition in mitochondria has been studied. It has been shown that in the presence of Ca2+, PA induces a swelling of mitochondria, which is not inhibited by cyclosporin A. The swelling is accompanied by a drop in membrane potential, which cannot be explained only by a work of the Ca2+ uniporter. With time, the potential is restored. Evidence has been obtained indicating that the specific content of mitochondrial lipids would favor the PA/Ca2+ -induced permeabilization of the membrane. In experiments with liposomes, the PA/Ca2+ -induced membrane permeabilization was larger for liposomes formed from the mitochondrial lipids, as compared to the azolectin liposomes. Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. The PA/Ca2+ -dependent mechanism of permeability transition in mitochondria might be related to some pathologies, e.g. myocardial ischemia. The heaviness of myocardial infarction of ischemic patients has been demonstrated to correlate directly with the content of PA in the human blood serum.
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