ReviewCellular and molecular life sciences : CMLS2004
Hemokinins and endokinins.
Review in Cellular and molecular life sciences : CMLS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 163 citations in OpenAlex.
- The effect of intra-articular botulinum toxin A on substance P, prostaglandin EBMC veterinary research · 2017Trial
- An atlas of genetic determinants of forearm fracture.Nature genetics · 2023Article
- Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.Frontiers in endocrinology · 2022Review
- Novel Pituitary Actions of TAC4 Gene Products in Teleost.International journal of molecular sciences · 2021Article
- Characteristics of Neurokinin-3 Receptor and Its Binding Sites by Mutational Analysis.Biology · 2021Article
- Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization.International journal of molecular sciences · 2020Article
- Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.Journal of clinical medicine · 2019Review
- Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts.Scientific reports · 2018Article
- Substance P Receptor in the Rat Heart and Regulation of Its Expression in Long-Term Diabetes.Frontiers in physiology · 2018Article
- Substance P Regulation in Epilepsy.Current neuropharmacology · 2018Review
- The role of neuropeptides in adverse myocardial remodeling and heart failure.Cellular and molecular life sciences : CMLS · 2017Review
- TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Plasma urotensin II and neurokinin B levels in acute myocardial infarction and stable coronary artery disease.Anatolian journal of cardiology · 2015Article
- Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model.BMC musculoskeletal disorders · 2014Article
- Substance P in heart failure: the good and the bad.International journal of cardiology · 2014Review
- Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.PloS one · 2014Article
- Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions.British journal of clinical pharmacology · 2014Review
- Bilateral increase in expression and concentration of tachykinin in a unilateral rabbit muscle overuse model that leads to myositis.BMC musculoskeletal disorders · 2013Article
- Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian tachykinins are a family of peptides that, until recently, has included substance P (SP), neurokinin A and neurokinin B. Since, the discovery of a third preprotachykinin gene ( TAC4), the number of tachykinins has more than doubled to reveal several species-divergent peptides. This group includes hemokinin-1 (HK-1) in mouse and rat, endokinin-1 (EK-1) in rabbit, and EKA, EKB, human HK-1 (hHK-1) and hHK(4-11) in humans. Each exhibits a remarkable selectivity and potency for the tachykinin NK(1) receptor similar to SP. Their peripheral expression has led to the proposal that they are the endogenous peripheral SP-like endocrine/paracrine agonists where SP is not expressed. Moreover, their strong cross-reactivity with a specific SP antibody leads us to question many of the proposed locations and roles of SP in the periphery. Additionally, three orphan tachykinin gene-related peptides are identified on TAC4, in rabbit, EK-2 and in humans, EKC and EKD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.