ReviewInternational journal of impotence research2004
Novel nitric oxide signaling mechanisms regulate the erectile response.
Review in International journal of impotence research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 154 citations in OpenAlex.
- Nebivolol compared with metoprolol for erectile function in males undergoing coronary artery bypass graft.Anatolian journal of cardiology · 2016Trial
- Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy.Signal transduction and targeted therapy · 2026Review
- An updated narrative review on revolutionizing erectile dysfunction treatment: the crucial role of trophic factors in Adipose-Derived stem cell therapy.BMC urology · 2025Review
- [Retrospective study on the impact of penile corpus cavernosum injection test on penile vascular function].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Hydrogen sulfide and its potential as a possible therapeutic agent in male reproduction.Frontiers in endocrinology · 2024Review
- Graphene nanocomposites for real-time electrochemical sensing of nitric oxide in biological systems.Applied physics reviews · 2023Article
- Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction.Disease markers · 2022Article
- Vitamin D and Male Erectile Function: An Updated Review.The world journal of men's health · 2021Review
- The Daily Therapy With L-Arginine 2,500 mg and Tadalafil 5 mg in Combination and in Monotherapy for the Treatment of Erectile Dysfunction: A Prospective, Randomized Multicentre Study.Sexual medicine · 2020Article
- Article
- Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats.Andrology · 2016Article
- Penile erectile dysfunction after brachial plexus root avulsion injury in rats.Neural regeneration research · 2014Article
- Effects of chronic treatment with the eNOS stimulator Impaza on penis length and sexual behaviors in rats with a high baseline of sexual activity.International journal of impotence research · 2014Article
- Erectile function is improved in aged rats by PnTx2-6, a toxin from Phoneutria nigriventer spider venom.The journal of sexual medicine · 2012Article
- Stuttering priapism: insights into pathogenesis and management.Current urology reports · 2012Review
- Article
- Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.The journal of sexual medicine · 2010Article
- Reversal of voltage-dependent erectile responses in the Zucker obese-diabetic rat by rosuvastatin-altered RhoA/Rho-kinase signaling.The journal of sexual medicine · 2009Article
- Erectile dysfunction in a murine model of sleep apnea.American journal of respiratory and critical care medicine · 2008Article
- Molecular Yin and Yang of erectile function and dysfunction.Asian journal of andrology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a physiologic signal essential to penile erection, and disorders that reduce NO synthesis or release in the erectile tissue are commonly associated with erectile dysfunction. NO synthase (NOS) catalyzes production of NO from L-arginine. While both constitutively expressed neuronal NOS (nNOS) and endothelial NOS (eNOS) isoforms mediate penile erection, nNOS is widely perceived to predominate in this role. Demonstration that blood-flow-dependent generation of NO involves phosphorylative activation of penile eNOS challenges conventional understanding of NO-dependent erectile mechanisms. Regulation of erectile function may not be mediated exclusively by neurally derived NO: Blood-flow-induced fluid shear stress in the penile vasculature stimulates phosphatidyl-inositol 3-kinase to phosphorylate protein kinase B, which in turn phosphorylates eNOS to generate NO. Thus, nNOS may initiate cavernosal tissue relaxation, while activated eNOS may facilitate attainment and maintenance of full erection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.