Evidence map›Paper›PMID 15223864›Full record

SynthesisThorax2004

Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis.

W Q Gan, S F P Man, A Senthilselvan, D D Sin

2 registry-linked trialsAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 662 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
662citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02593357 nacompletednot on this mapstarted 2012, after this paper: background citation

Assessment of a Peripheral Endothelial Dysfunction in COPD (Chronic Obstructive Pulmonary Disease)

TypeinterventionalSponsorHopital FochRan2012 to 2017Enrolled137ConditionsChronic Obstructive Pulmonary DiseaseArmsCOPD patients
NCT03014609 recruitingnot on this mapstarted 2017, after this paper: background citation

Cardiovascular Risk and Chronic Obstructive Pulmonary Disease (COPD)

Typeobservational_patient_registrySponsorUniversity Hospital, GrenobleRan2017 to 2029Enrolled150ConditionsChronic Obstructive Pulmonary Disease
3 · Its place in the literature

Who cites it

662 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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602 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

W Q GanThe James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul's Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6.
S F P Man
A Senthilselvan
D D Sin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular diseases, osteoporosis, and muscle wasting. Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD.

methodsA systematic review was conducted of studies which reported on the relationship between COPD, forced expiratory volume in 1 second (FEV(1)) or forced vital capacity (FVC), and levels of various systemic inflammatory markers: C-reactive protein (CRP), fibrinogen, leucocytes, tumour necrosis factor-alpha (TNF-alpha), and interleukins 6 and 8. Where possible the results were pooled together to produce a summary estimate using a random or fixed effects model.

resultsFourteen original studies were identified. Overall, the standardised mean difference in the CRP level between COPD and control subjects was 0.53 units (95% confidence interval (CI) 0.34 to 0.72). The standardised mean difference in the fibrinogen level was 0.47 units (95% CI 0.29 to 0.65). Circulating leucocytes were also higher in COPD than in control subjects (standardised mean difference 0.44 units (95% CI 0.20 to 0.67)), as were serum TNF-alpha levels (standardised mean difference 0.59 units (95% CI 0.29 to 0.89)).

conclusionsReduced lung function is associated with increased levels of systemic inflammatory markers which may have important pathophysiological and therapeutic implications for subjects with stable COPD.

Indexed as

C-Reactive ProteinCytokinesFibrinogenForced Expiratory VolumeHumansInflammationLeukocytesPulmonary Disease, Chronic ObstructiveVital CapacityC-Reactive ProteinCytokinesFibrinogen

Identifiers

PMID15223864
PMCPMC1747070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.