ArticleThe Biochemical journal2004
Fibroblast growth factor-2(23) binds directly to the survival of motoneuron protein and is associated with small nuclear RNAs.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA).Cellular and molecular life sciences : CMLS · 2022Review
- Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner.Neuropharmacology · 2018Article
- A nuclear odyssey: fibroblast growth factor-2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system.Cellular and molecular life sciences : CMLS · 2015Review
- Immobile survival of motoneuron (SMN) protein stored in Cajal bodies can be mobilized by protein interactions.Cellular and molecular life sciences : CMLS · 2013Article
- Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons.The Journal of biological chemistry · 2012Article
- Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.PloS one · 2012Article
- Phosphorylation and the Cajal body: modification in search of function.Archives of biochemistry and biophysics · 2010Review
- Fibroblast growth factor-2 regulates the stability of nuclear bodies.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?Nature reviews. Neuroscience · 2009Review
- Direct and heterologous approaches to identify the LET-756/FGF interactome.BMC genomics · 2006Article
- Motoneuron injury and repair: New perspectives on gonadal steroids as neurotherapeutics.Journal of molecular neuroscience : MN · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SMN (survival of motoneuron) protein is mutated in patients with the neurodegenerative disease spinal muscular atrophy. We have shown previously that a high-molecular-mass isoform of FGF (fibroblast growth factor) 2 (FGF-2(23)) is in a complex with SMN [Claus, Doring, Gringel, Muller-Ostermeyer, Fuhlrott, Kraft and Grothe (2003) J. Biol. Chem. 278, 479-485]. FGF-2 is a neurotrophic factor for motoneurons, and is known not only as a classical extracellular growth factor, but also as a nuclear protein. In the present study, we demonstrate that SMN binds to the arginine-rich N-terminus of FGF-2(23). In turn, FGF-2(23) interacts with amino acid residues 1-90 of the human SMN protein. This sequence displays nucleic-acid-binding capacity and overlaps partially with known binding sites for Gemin2/SIP1 (SMN-interacting protein 1) and p53. Finally, as a functional consequence of FGF-2(23) binding to SMN, FGF-2(23) is in a complex with the small nuclear RNAs U2 and U4. Since SMN functions as an assembly factor for snRNPs (small nuclear ribonucleoprotein particles), these results suggest binding of FGF-2(23) to snRNPs.
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