ArticleWorld journal of gastroenterology2004
Relationship between serum calcium and CA 19-9 levels in colorectal cancer.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies.Epidemiology and health · 2023Pooled it
- Vitamin D and Calcium as Key Potential Factors Related to Colorectal Cancer Prevention and Treatment: A Systematic Review.Nutrients · 2022Pooled it
- Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer.BioMed research international · 2019Trial
- Zinc, copper, copper-to-zinc ratio, and other biometals in blood serum and tumor tissue of patients with colorectal cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Increased thyroid malignancy in patients with primary hyperparathyroidism.Endocrine connections · 2021Article
- Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer.Saudi journal of biological sciences · 2020Article
- Quantitative assessment of the clinical susceptibility of calcium-sensing receptor polymorphisms in cancer patients.Cancer management and research · 2018Article
- Serum Calcium and Risk of Nonmedullary Thyroid Cancer in Patients with Primary Hyperparathyroidism.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Alanine to Serine Variant at Position 986 of Calcium Sensing Receptor and Colorectal Cancer Risk.Iranian journal of cancer prevention · 2016Article
- A calculation model for serum ionized calcium based on an equilibrium equation for complexation.Analytical chemistry insights · 2012Article
- CARD15 mutations and colorectal cancer in a South European country.International journal of colorectal disease · 2010Article
- Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry.Carcinogenesis · 2010Article
- Risk factors for pancreatic adenocarcinoma and prospects for screening.Gastroenterology & hepatology · 2010Article
- Genetic variation in calcium-sensing receptor and risk for colon cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- Article
- Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients.
methodsSeventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above.
resultsA lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined.
conclusionBased on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.
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