ArticleHistochemistry and cell biology2004
Typing of hepatic nonparenchymal cells using fibulin-2 and cytoglobin/STAP as liver fibrogenesis-related markers.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Oxidative Stress and Inflammation in Uterine-Vascular Adaptation During Pregnancy.Antioxidants (Basel, Switzerland) · 2025Review
- Sex-specific extracellular matrix remodeling during early adipogenic differentiation by gestational bisphenol A exposure.Chemosphere · 2022Article
- Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.Clinical and molecular hepatology · 2020Review
- Cytoglobin: a potential marker for adipogenic differentiation in preadipocytes in vitro.Cytotechnology · 2017Article
- Article
- Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts.Frontiers in physiology · 2015Review
- Cytoglobin in tumor hypoxia: novel insights into cancer suppression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action.World journal of gastroenterology · 2012Article
- Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family.Cellular and molecular life sciences : CMLS · 2011Review
- Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.The American journal of pathology · 2011Article
- Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells.Cell and tissue research · 2009Article
- Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors.British journal of pharmacology · 2009Article
- Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?Neoplasia (New York, N.Y.) · 2008Article
- Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts.Histochemistry and cell biology · 2007Article
- Cytoglobin is a stress-responsive hemoprotein expressed in the developing and adult brain.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2006Article
- Article
- Article
- Recent progress in histochemistry and cell biology: the state of the art 2005.Histochemistry and cell biology · 2005Review
- News and views in Histochemistry and Cell Biology.Histochemistry and cell biology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibulin-2 and cytoglobin/stellate cell activation-associated protein (Cygb/STAP) are considered to be markers of hepatic myofibroblasts (MFs) and stellate cells (HSCs), respectively. The aim of the present study was to characterize the nonparenchymal cells (NPCs) of normal rat livers and carbon tetrachloride-induced fibrotic rat livers with respect to the expression of these two proteins. NPCs in normal (Glisson's capsules) and fibrotic (fibrotic septa) connective tissues were immunohistochemically categorized into four cell types in terms of the expression of fibulin-2 and Cygb/STAP: fibulin-2 and Cygb/STAP double-positive (Fib(+)/STAP(+)); fibulin-2-positive and Cygb/STAP-negative (Fib(+)/STAP(-)); Fib(-)/STAP(+); and Fib(-)/STAP(-). The Glisson's capsules had Fib(+)/STAP(+) and Fib(-)/STAP(-) cell occupancy rates of 45.5% and 54.5%, respectively, but did not contain Fib(+)/STAP(-) or Fib(-)/STAP(+) cells. On the other hand, the fibrotic septa contained Fib(+)/STAP(+), Fib(-)/STAP(+), and Fib(-)/STAP(-) cells at occupancy rates of 35.0%, 50.5%, and 9.1%, respectively, but did not contain Fib(+)/STAP(-) cells. Thus, fibrosis is characterized by a dramatic increase in Fib(-)/STAP(+) NPCs, and a dramatic decrease in Fib(-)/STAP(-) NPCs. Fib(+)/STAP(+) NPCs are located uniformly in Glisson's capsules and peripherally in fibrotic septa. The present study strongly suggests that Fib(+)/STAP(+) and Fib(-)/STAP(+) NPCs correspond to MFs and activated HSCs, respectively, both of which may contribute to liver fibrogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.