ArticleVirchows Archiv : an international journal of pathology2004
Correlation between the DNA global methylation status and progesterone receptor expression in normal endometrium, endometrioid adenocarcinoma and precursors.
Article in Virchows Archiv : an international journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Acute biological age as a determinant of adverse outcomes requiring hospitalization in Danish emergency department patients.Communications medicine · 2026Article
- Understanding epigenetic regulation in the endometrium - lessons from mouse models with implantation defects.Epigenomics · 2025Review
- Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure.Journal of molecular histology · 2024Article
- The role of epigenetics in women's reproductive health: the impact of environmental factors.Frontiers in endocrinology · 2024Review
- Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer.Frontiers in oncology · 2024Review
- Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress.Epigenetics · 2023Article
- Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility.International journal of molecular sciences · 2022Review
- Abnormally increased DNA methylation in chorionic tissue might play an important role in development of ectopic pregnancy.Reproductive biology and endocrinology : RB&E · 2021Article
- The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium.Clinical epigenetics · 2021Review
- Non-Coding RNAs as Prognostic Markers for Endometrial Cancer.International journal of molecular sciences · 2021Review
- Epigenetic control of embryo-uterine crosstalk at peri-implantation.Cellular and molecular life sciences : CMLS · 2019Review
- DNA Methylation Inhibitor 5-Aza-2'-Deoxycytidine Modulates Endometrial Receptivity Through Upregulating HOXA10 Expression.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- New concepts for an old problem: the diagnosis of endometrial hyperplasia.Human reproduction update · 2017Review
- Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition.Human genetics · 2015Article
- Endometrial Endometrioid Carcinoma Metastases Show Decreased ER-Alpha and PR-A Expression Compared to Matched Primary Tumors.PloS one · 2015Article
- Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.Biomolecular concepts · 2014Review
- The elusive and controversial roles of estrogen and progesterone receptors in human endometriosis.American journal of translational research · 2014Review
- Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.Gene expression patterns : GEP · 2013Article
- Linking DNA methylation to the onset of human tubal ectopic pregnancy.American journal of translational research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometrial carcinomas are the most common malignancy of the female genital tract and the third most common cancer in women. Progesterone and oestrogen receptors (PRs, ERs) are the most widely documented prognostic and predictive factors in endometrioid adenocarcinoma. Besides the hormonal pathway involved in the progression of preneoplastic and neoplastic lesions, alterations of the DNA methylation status have been shown to be an early signal of tumorigenesis. In this study, we show that in normal endometrium, during the proliferative phase, DNA methylation and PR expression are high, with a significant decline towards the end of the secretory phase and a gradual increase in non-atypical and atypical endometrial hyperplasia; they reach their highest level in grade I, then decrease significantly in grade-II and grade-III endometrioid adenocarcinomas. During each stage, a significant positive correlation is observed between DNA methylation and PR (P<0.0001). The strong parallelism between DNA methylation and PR expression precludes establishing a precise determination regarding the timing of these events, clearly involved in the genesis of endometrioid adenocarcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.