Evidence map›Paper›PMID 15221292›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2004

Challenging the neuronal MIBG uptake by pharmacological intervention: effect of a single dose of oral amitriptyline on regional cardiac MIBG uptake.

Montserrat Estorch, Ignasi Carrió, Esther Mena, Albert Flotats, Valle Camacho, Jordi Fuertes, Jaume Kulisewsky, Jagat Narula

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. EANM 2012 guidelines for radionuclide imaging of phaeochromocytoma and paraganglioma.European journal of nuclear medicine and molecular imaging · 2012
    Guideline
  2. Review
  3. Review
  4. Article
  5. Impact of medications on mIBG uptake, with specific attention to the heart: Comprehensive review of the literature.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015
    Review
  6. Review
  7. Article
  8. Cardiac neurotransmission SPECT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Montserrat EstorchDepartment of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, Spain. mestorch@hsp.santpau.es
Ignasi Carrió
Esther Mena
Albert Flotats
Valle Camacho
Jordi Fuertes
Jaume Kulisewsky
Jagat Narula
Universitat Autònoma de Barcelona · ESHospital de Sant Pau · ESUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImaging with metaiodobenzylguanidine (MIBG) is used for the assessment of neuronal dysfunction in various cardiovascular disorders. Although valuable information is obtained by resting MIBG imaging, it is conceivable that competitive interference with the re-uptake mechanism would exaggerate MIBG defects and might unmask subclinical neuronal dysfunction. Tricyclic antidepressants, such as amitriptyline, have been reported to significantly increase cardiac MIBG washout and inhibit uptake into presynaptic neurons. This study was undertaken to assess whether a single oral dose of amitriptyline could influence cardiac MIBG distribution.

methodsSix patients (aged 62-81 years; four males, two females) who had demonstrated a normal cardiac MIBG scan during work-up for movement disorders were studied. The patients underwent a second 123I-MIBG study after oral administration of 25 mg amitriptyline within 1 week. Single-photon emission computed tomography images were acquired at 4 h to assess the regional distribution of MIBG, after generation of polar maps and employing a 20-segment model. Mean percentage of peak activity was calculated for each segment at rest and after amitriptyline administration.

resultsAfter amitriptyline administration, there was a decrease in regional MIBG uptake in 10+/-4 segments per patient [62/120 segments (52%): 37 segments with a 5-10% decrease, 25 segments with a >10% decrease]. This change was statistically significant in lateral (P=0.003), apical (P<0.0001) and inferior (P=0.03) regions.

conclusionA single oral dose of amitriptyline can induce changes in the uptake and retention of cardiac MIBG, indicating the feasibility of use of pharmacological intervention in cardiac neurotransmission imaging.

Indexed as

Artifacts3-IodobenzylguanidineAdministration, OralAgedAged, 80 and overAmitriptylineAntidepressive Agents, TricyclicFemaleHeartHeart Conduction SystemHumansMaleMiddle AgedMyocardiumRadionuclide ImagingRadiopharmaceuticals3-IodobenzylguanidineAmitriptylineAntidepressive Agents, TricyclicRadiopharmaceuticals

Identifiers

PMID15221292
OpenAlexW1977411575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.