ArticleThe Journal of cell biology1992
Identification of an epithelial protein related to the desmosome and intermediate filament network.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.Cell metabolism · 2021Article
- Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion.Journal of cellular and molecular medicine · 2021Article
- Article
- Pinin promotes tumor progression via activating CREB through PI3K/AKT and ERK/MAPK pathway in prostate cancer.American journal of cancer research · 2021Article
- piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis.Nature cell biology · 2020Article
- Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions.Journal of biomedical science · 2019Article
- Article
- Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.Oncotarget · 2016Article
- Dissection of the role of Pinin in the development of zebrafish posterior pharyngeal cartilages.Histochemistry and cell biology · 2012Article
- Recent progress in histochemistry and cell biology.Histochemistry and cell biology · 2012Review
- Pnn and SR family proteins are differentially expressed in mouse central nervous system.Histochemistry and cell biology · 2011Article
- Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn.Investigative ophthalmology & visual science · 2010Article
- Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.Molecular and cellular biology · 2008Article
- Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.Molecular and cellular biology · 2004Article
- Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1.Molecular and cellular biology · 2003Article
- Change in gene expression subsequent to induction of Pnn/DRS/memA: increase in p21(cip1/waf1).Oncogene · 2001Article
- The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells.Molecular biology of the cell · 2000Article
- Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function.Oncogene · 2000Article
- The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Using a mAb, referred to as 08L, we have identified a protein, of M(r) approximately 140,000, associated with desmosomes of epithelial cells. The 08L antibody stained the intracellular side of lateral cell margins of monolayer epithelial cells but did not stain cell margins free of cell contact. Immunoelectron microscopy revealed that the 08L antigen was localized to the cytosolic surface of the desmosomal plaque near points of intermediate filament convergence with apparently little staining of the desmosomal plaque proper. Western blots revealed the 08L antigen to be a protein, of M(r) approximately 140,000, found in the Triton-X 100 insoluble pellet. High salt-containing buffers extracted the 08L antigen from the insoluble material. Examination of the assembly of 08L to the desmosome complex, in cells grown in low confluent culture or in calcium-switch assays, by double immunofluorescence with 08L and anti-desmoplakin antibody, revealed that 08L was recruited to morphologically identifiable desmosomes. 08L antigen may exist in a cytosolic pool prior to assembly to the cell surface. The solubility of 08L in low calcium and normal calcium conditions, however, was similar. 08L association to the desmosome was correlated with increased organization of the intermediate filament network. We suggest that the 08L antigen may be involved in the organization and stabilization of the desmosome-IF complexes of epithelia.
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