ArticleExperimental brain research2004
Movement-related and preparatory activity in the reticulospinal system of the monkey.
Article in Experimental brain research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- What Is the StartReact Effect?Acta physiologica (Oxford, England) · 2026Review
- Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement.Nature communications · 2026Article
- Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training.Brain research · 2026Article
- Mapping reticulospinal drive across various muscles of the upper and lower extremities.Experimental physiology · 2025Article
- Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic stroke.Experimental brain research · 2025Article
- Evolution, biomechanics, and neurobiology converge to explain selective finger motor control.Physiological reviews · 2024Review
- Muscle synergies are associated with intermuscular coherence and cortico-synergy coherence in an isometric upper limb task.Experimental brain research · 2023Article
- Express Visuomotor Responses Reflect Knowledge of Both Target Locations and Contextual Rules during Reaches of Different Amplitudes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Existence of the StartReact Effect Implies Reticulospinal, Not Corticospinal, Inputs Dominate Drive to Motoneurons during Voluntary Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Startling stimuli increase maximal motor unit discharge rate and rate of force development in humans.Journal of neurophysiology · 2022Article
- Modulation of neural co-firing to enhance network transmission and improve motor function after stroke.Neuron · 2022Review
- Article
- Long-latency Responses to a Mechanical Perturbation of the Index Finger Have a Spinal Component.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Rapid crossed responses in an intrinsic hand muscle during perturbed bimanual movements.Journal of neurophysiology · 2020Article
- The mammalian spinal commissural system: properties and functions.Journal of neurophysiology · 2020Review
- Stabilizing stretch reflexes are modulated independently from the rapid release of perturbation-triggered motor plans.Scientific reports · 2019Article
- High-intensity transcranial magnetic stimulation reveals differential cortical contributions to prepared responses.Journal of neurophysiology · 2019Article
- Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation.Annals of neurology · 2019Article
- The Relationship Between Blood Flow and Motor Unit Firing Rates in Response to Fatiguing Exercise Post-stroke.Frontiers in physiology · 2019Article
- Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Three monkeys ( M. fascicularis) performed a center-out, two-dimensional reaching task that included an instructed delay interval based on a color-coded visuospatial cue. Neural activity in the medial pontomedullary reticular formation (mPMRF) was recorded along with hand movement. Of 176 neurons with movement-related activity, 109 (62%) had movement-related but not preparatory activity (M cells), and 67 (38%) had both movement-related and preparatory activity (MP cells). EOG analyses indicated that the preparatory activity was not consistent with control of eye movements. There were slight changes in electromyograms (EMG) late in the instructed delay period before the Go cue, but these were small compared with the movement-related EMG activity. Preparatory activity, like the EMG activity, was also confined to the end of the instructed delay period for 14 MP cells, but the remaining 53 MP cells (30%) had preparatory activity that was not reflected in the EMG. Peri-movement neural activity varied with movement direction for 70% of the cells, but this variation rarely fit circular statistics commonly used for studies of directional tuning; directional tuning was even less common in the preparatory activity. These data show that neurons in the mPMRF are strongly modulated during small reaching movements, but this modulation was rarely correlated with the trajectory of the hand. In accord with findings in the literature from other regions of the CNS, evidence of activity related to motor preparation in these cells indicates that this function is distributed in the nervous system and is not a feature limited to the cerebral cortex.
Indexed as
Identifiers
15221165What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.