Evidence map›Paper›PMID 15220455›Full record

ArticleJournal of virology2004

Biased hypermutagenesis associated with mutations in an untranslated hairpin of an RNA virus.

John C McCormack, Anne E Simon

Abstract read
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John C McCormackDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Anne E Simon

Funding

Role of RNA Structural Switches in the Replication of a (+)-Strand RNA VirusR01GM061515 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI SIMON, ANNE ELIZABETH · 2002 to 2010
$2.4M
Mechanisms of Virus Replication and Gene ExpressionT32AI051967 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SIMON, ANNE ELIZABETH · 2002 to 2013
$1.8M
NIAID NIH HHS T32 AI051967NIAID NIH HHS T32AI51967NIGMS NIH HHS R01 GM061515NIGMS NIH HHS R01 GM61515-01
6 · The paper itself

Abstract

The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations. These results suggest that the hairpin may also function as an RNA chaperone to properly fold the RNA-dependent RNA polymerase.

Indexed as

MutagenesisPoint Mutation3' Untranslated RegionsBase SequenceBrassica napusCarmovirusGene Expression Regulation, ViralMolecular Sequence DataRNA, CatalyticRNA-Dependent RNA PolymeraseRNA, Viral3' Untranslated Regionshairpin ribozymeRNA, CatalyticRNA-Dependent RNA PolymeraseRNA, Viral

Identifiers

PMID15220455
PMCPMC434097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.