ArticleJournal of virology2004
Human cytomegalovirus carries a cell-derived phospholipase A2 required for infectivity.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Targeting phospholipase A2 with arachidonyl trifluoromethyl ketone modulates macrophage activation during Japanese encephalitis virus infection.Medical microbiology and immunology · 2026Article
- Valspodar limits human cytomegalovirus infection and dissemination.Antiviral research · 2021Article
- PPAR Gamma and Viral Infections of the Brain.International journal of molecular sciences · 2021Review
- Cytomegalovirus infection: friend or foe in rheumatoid arthritis?Arthritis research & therapy · 2021Review
- Insights into the antiviral activity of phospholipases AInternational journal of biological macromolecules · 2020Review
- PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.PLoS pathogens · 2016Article
- The Cellular Proteins Grb2 and DDX3 Are Increased upon Human Cytomegalovirus Infection and Act in a Proviral Fashion.PloS one · 2015Article
- Article
- Dengue virus infection perturbs lipid homeostasis in infected mosquito cells.PLoS pathogens · 2012Article
- Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.Journal of lipid research · 2010Article
- Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas.Journal of virology · 2010Article
- Early transcriptional response in the jejunum of germ-free piglets after oral infection with virulent rotavirus.Archives of virology · 2008Article
- Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion.Journal of virology · 2005Article
- vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus.Journal of virology · 2005Article
- Plunder and stowaways: incorporation of cellular proteins by enveloped viruses.Journal of virology · 2005Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cytomegalovirus (HCMV) is known to carry host cell-derived proteins and mRNAs whose role in cell infection is not understood. We have identified a phospholipase A2 (PLA2) activity borne by HCMV by using an assay based on the hydrolysis of fluorescent phosphatidylcholine. This activity was found in all virus strains analyzed and in purified strains. It was calcium dependent and was sensitive to inhibitors of cytosolic PLA2 (cPLA2) but not to inhibitors of soluble PLA2 or calcium-independent PLA2. No other phospholipase activity was detected in the virus. Purified virus was found to contain human cellular cPLA2alpha, as detected by monoclonal antibody. No homology with PLA2 was found in the genome of HCMV, indicating that HCMV does not code for a PLA2. Decreased de novo expression of immediate-early proteins 1 and 2 (IE1 and IE2), tegument phosphoprotein pp65, and virus production was observed when HCMV was treated with inhibitors of cPLA2. Cell entry of HCMV was not altered by those inhibitors, suggesting the action of cPLA2 was postentry. Together, our results indicate a selective sorting of a cell-derived cPLA2 during HCMV maturation, which is further required for infectivity.
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