ArticleJournal of virology2004
Isolation of multiple TT virus genotypes from spleen biopsy tissue from a Hodgkin's disease patient: genome reorganization and diversity in the hypervariable region.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 97 citations in OpenAlex.
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Evolution of anelloviruses from a circovirus-like ancestor through gradual augmentation of the jelly-roll capsid protein.Virus evolution · 2023Article
- Phylogenetic analysis of torque teno virus in Romania: possible evidence of distinct geographical distribution.Archives of virology · 2022Article
- Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation.Microbiome · 2022Article
- Detection and genetic characterization of the novel torque teno virus group 6 in Taiwanese general population.Royal Society open science · 2021Article
- Taxonomic Changes for Human and Animal Viruses, 2018 to 2020.Journal of clinical microbiology · 2021Review
- Bidirectional transfer of Anelloviridae lineages between graft and host during lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue.Emerging microbes & infections · 2019Article
- Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis.Virus genes · 2017Article
- Arenavirus Quasispecies and Their Biological Implications.Current topics in microbiology and immunology · 2016Review
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- Molecular characterization of human Torque Teno virus.Biomedical reports · 2015Article
- High-throughput sequencing exclusively identified a novel Torque teno virus genotype in serum of a patient with fatal fever.Virologica Sinica · 2014Article
- Genetic variation in vitro and in vivo of an attenuated Lassa vaccine candidate.Journal of virology · 2014Article
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- Management strategies in the treatment of neonatal and pediatric gastroenteritis.Infection and drug resistance · 2013Review
- Molecular investigation of Torque teno sus virus in geographically distinct porcine breeding herds of Sichuan, China.Virology journal · 2013Article
- Arenavirus variations due to host-specific adaptation.Viruses · 2013Review
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- Phylogenetic analysis of Torque Teno Virus genome from Pakistani isolate and incidence of co-infection among HBV/HCV infected patients.Virology journal · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the isolation of 24 novel genotypes of TT viruses from a surgically removed spleen of a patient with Hodgkin's disease. The sequence analysis of our 24 isolates revealed the remarkable heterogeneity of TT virus isolates not only from the same patient but also from the same biopsy material. These isolates belong to four phylogenetic groups of TT viruses. Nucleotide sequence analyses revealed five distinct genotypes (tth3, tth4, tth5, tth6, and tth7). The limited variation in sequence identity of the other isolates defines the latter as variants of four of these genotypes. A group of 6 isolates (the tth7 group) revealed a reorganization of open reading frame 1 (ORF1) leading to one larger and a varying number of smaller ORFs. The nucleotide difference of the full-length genomes was less than 1%. A variation of 69 to 97% in amino acids of a second group of 8 isolates (the tth3 group) was restricted to the hypervariable region of ORF1, indicating the existence of a quasi-species. These isolates differed by less than 2% in the remainder of their nucleotide sequences. An alignment of these isolates with 79 previously reported TT virus genotypes permits the proposal of TT virus genera and species within the family Anelloviridae in analogy to a previous proposal for the papillomaviruses (family Papillomaviridae).
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