ArticleCell communication and signaling : CCS2004
Mitogen Activated Protein kinase signal transduction pathways in the prostate.
Article in Cell communication and signaling : CCS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs.Cell biochemistry and biophysics · 2025Article
- Signaling Pathways and Targeted Therapies for Stem Cells in Prostate Cancer.ACS pharmacology & translational science · 2022Review
- Inhibition of Human Prostate and Bladder Smooth Muscle Contraction, Vasoconstriction of Porcine Renal and Coronary Arteries, and Growth-Related Functions of Prostate Stromal Cells by Presumed Small Molecule GαFrontiers in physiology · 2022Article
- Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells.Toxicology and applied pharmacology · 2020Article
- Inhibiting MAPK14 showed anti-prolactinoma effect.BMC endocrine disorders · 2020Article
- Activation of the Erk/MAPK signaling pathway is a driver for cadmium induced prostate cancer.Toxicology and applied pharmacology · 2020Article
- p38 Expression and Modulation of STAT3 Signaling in Oral Cancer.Pathology oncology research : POR · 2020Article
- Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Chinese Herbal MedicineInternational journal of molecular sciences · 2019Article
- Role of MAPK/MNK1 signaling in virus replication.Virus research · 2018Review
- CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells.Mediators of inflammation · 2018Article
- p38-MAPK/MSK1-mediated overexpression of histone H3 serine 10 phosphorylation defines distance-dependent prognostic value of negative resection margin in gastric cancer.Clinical epigenetics · 2016Article
- Cytokine effects on cell viability and death of prostate carcinoma cells.BioMed research international · 2014Article
- Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population.PloS one · 2014Article
- Role of p38 MAP Kinase Signal Transduction in Solid Tumors.Genes & cancer · 2013Review
- Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer.Frontiers in endocrinology · 2013Article
- Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3.British journal of pharmacology · 2012Article
- Oxidative stress in prostate cancer.Cancer letters · 2009Review
- Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes.The American journal of pathology · 2008Article
- Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage.Arthritis and rheumatism · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease. We reviewed articles examining mitogen-activated protein kinases using prostate tissue or cell lines. As with other tissue types, these signaling modules are links/transmitters for important pathways in prostate cells that can result in cellular survival or apoptosis. While the activation of the ERK pathway appears to primarily result in survival, the roles of JNK and p38 are less clear. Manipulation of these pathways could have important implications for the treatment of prostate cancer and benign prostatic hypertrophy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.