Evidence map›Paper›PMID 15219234›Full record

ReviewRetrovirology2004

HIV-1 gene expression: lessons from provirus and non-integrated DNA.

Yuntao Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Retrovirology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 117 citations in OpenAlex.

  1. Trial
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  7. Article
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  13. Article
  14. Deciphering DNA Methylation in HIV Infection.Frontiers in immunology · 2021
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Absence of LEDGF/p75 Expression in Astrocytes May Affect HIV-1 Integration Efficiency.Molecular genetics, microbiology and virology : Molekulyarnaya genetika, mikrobiologiya i virusologiya · 2019
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Yuntao WuCenter for Biodefense, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA. ywu8@gmu.edu
George Mason University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replication of HIV-1 involves a series of obligatory steps such as reverse transcription of the viral RNA genome into double-stranded DNA, and subsequent integration of the DNA into the human chromatin. Integration is an essential step for HIV-1 replication; yet the natural process of HIV-1 infection generates both integrated and high levels of non-integrated DNA. Although proviral DNA is the template for productive viral replication, the non-integrated DNA has been suggested to be active for limited viral gene synthesis. In this review, the regulation of viral gene expression from proviral DNA will be summarized and issues relating to non-integrated DNA as a template for transcription will be discussed, as will the possible function of pre-integration transcription in HIV-1 replication cycle.

Indexed as

Gene Expression Regulation, ViralAnimalsDNA, ViralHIV-1HumansLife Cycle StagesProvirusesTranscription, GeneticVirus IntegrationDNA, Viral

Identifiers

PMID15219234
PMCPMC449739
OpenAlexW2145464880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.