ArticleThe Journal of physiology2004
Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- How to train your neuron: developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells.Frontiers in computational neuroscience · 2026Article
- Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6).International journal of molecular sciences · 2022Review
- Dendritic Excitability and Synaptic Plasticity In Vitro and In Vivo.Neuroscience · 2022Review
- Modeling Dendrites and Spatially-Distributed Neuronal Membrane Properties.Advances in experimental medicine and biology · 2022Review
- Sodium sensitivity of KJournal of neurophysiology · 2021Article
- Effects ofJournal of neurophysiology · 2021Article
- Physiology and Therapeutic Potential of SK, H, and M Medium AfterHyperPolarization Ion Channels.Frontiers in molecular neuroscience · 2021Review
- Flexible Stoichiometry: Implications for KCNQ2- and KCNQ3-Associated Neurodevelopmental Disorders.Developmental neuroscience · 2021Review
- The Role of KFrontiers in physiology · 2020Review
- Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex.Journal of neurophysiology · 2018Article
- Modulation of Kv7 channels and excitability in the brain.Cellular and molecular life sciences : CMLS · 2017Review
- Article
- Analogous synaptic plasticity profiles emerge from disparate channel combinations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.Frontiers in cellular neuroscience · 2015Article
- M-type potassium conductance controls the emergence of neural phase codes: a combined experimental and neuron modelling study.Journal of the Royal Society, Interface · 2014Article
- Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Physiological characterization of vestibular efferent brainstem neurons using a transgenic mouse model.PloS one · 2014Article
- Neuromodulation of early electrosensory processing in gymnotiform weakly electric fish.The Journal of experimental biology · 2013Review
- Coordinated development of voltage-gated Na+ and K+ currents regulates functional maturation of forebrain neurons derived from human induced pluripotent stem cells.Stem cells and development · 2013Article
- The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.British journal of pharmacology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Voltage-dependent K(+) channels in the apical dendrites of CA1 pyramidal neurones play important roles in regulating dendritic excitability, synaptic integration, and synaptic plasticity. Using cell-attached, voltage-clamp recordings, we found a large variability in the waveforms of macroscopic K(+) currents in the dendrites. With single-channel analysis, however, we were able to identify four types of voltage-dependent K(+) channels and we categorized them as belonging to delayed-rectifier, M-, D-, or A-type K(+) channels previously described from whole-cell recordings. Delayed-rectifier-type K(+) channels had a single-channel conductance of 19 +/- 0.5 pS, and made up the majority of the sustained K(+) current uniformly distributed along the apical dendrites. The M-type K(+) channels had a single-channel conductance of 11 +/- 0.8 pS, did not inactivate with prolonged membrane depolarization, deactivated with slow kinetics (time constant 100 +/- 6 ms at -40 mV), and were inhibited by bath-applied muscarinic agonist carbachol (10 microm). The D-type K(+) channels had a single-channel conductance of around 18 pS, and inactivated with a time constant of 98 +/- 4 ms at +54 mV. The A-type K(+) channels had a single-channel conductance of 6 +/- 0.6 pS, inactivated with a time constant of 23 +/- 2 ms at +54 mV, and contributed to the majority of the transient K(+) current previously described. These results suggest both functional and molecular complexity for K(+) channels in dendrites of CA1 pyramidal neurones.
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