ArticleThe Journal of physiology2004
Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage.Metabolites · 2023Article
- Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart.Frontiers in physiology · 2021Article
- Article
- Metabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy.Journal of radiation research · 2020Article
- Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes.Frontiers in immunology · 2020Review
- Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection.Oncotarget · 2019Review
- Comparative effect of selenium and glycine on hydrogen peroxide-induced cell death and activation of macrophage U937 cells.Journal, genetic engineering & biotechnology · 2017Article
- Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.Oxidative medicine and cellular longevity · 2017Review
- Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines.Journal of the American Heart Association · 2016Article
- The role of glycine in regulated cell death.Cellular and molecular life sciences : CMLS · 2016Review
- Metabolomic approach to profile functional and metabolic changes in heart failure.Journal of translational medicine · 2015Article
- Evaluation of toxicological effects induced by tributyltin in clamToxicology reports · 2014Article
- Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats.Journal of biomedical research · 2012Article
- Glycine preconditioning to ameliorate pulmonary ischemia reperfusion injury in rats.Interactive cardiovascular and thoracic surgery · 2012Article
- Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge.British journal of pharmacology · 2012Review
- Glycine inhibits the LPS-induced increase in cytosolic Ca2+ concentration and TNFalpha production in cardiomyocytes by activating a glycine receptor.Acta pharmacologica Sinica · 2009Article
- Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes.The Journal of physiology · 2009Article
- Glycine and glycine receptor signalling in non-neuronal cells.Frontiers in molecular neuroscience · 2009Article
- Effects of hypoxia, glucose deprivation and acidosis on phosphatidylcholine synthesis in HL-1 cardiomyocytes. CTP:phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption.The Biochemical journal · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-ischaemic reperfusion may precipitate cardiomyocyte death upon correction of intracellular acidosis due in part to mitochondrial permeability transition. We investigated whether glycine, an amino acid with poorly understood cytoprotective properties, may interfere with this mechanism. In cardiomyocyte cultures, addition of glycine during re-energization following 1 h of simulated ischaemia (NaCN/2-deoxyglucose, pH 6.4) completely prevented necrotic cell death associated with pH normalization. Glycine also protected against cell death associated with pH normalization in reoxygenated rat hearts. Glycine prevented cyclosporin-sensitive swelling and calcein release associated with re-energization in rat heart mitochondria submitted to simulated ischaemia or to Ca(2+) stress under normoxia. NMR spectroscopy revealed a marked glycine depletion in re-energized cardiomyocytes that was reversed by exposure to 3 mm glycine. These results suggest that intracellular glycine exerts a previously unrecognized inhibition on mitochondrial permeability transition in cardiac myocytes, and that intracellular glycine depletion during myocardial hypoxia/reoxygenation makes the cell more vulnerable to necrotic death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.