ArticleBreast cancer research : BCR2004
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
Article in Breast cancer research : BCR, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Association between ATM polymorphisms and cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Evaluation of functional genetic variants for breast cancer risk: results from the Shanghai breast cancer study.American journal of epidemiology · 2011Article
- Variants in the ATM gene and breast cancer susceptibility.Genome medicine · 2009Article
- Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.Human mutation · 2009Article
- ATM sequence variants associate with susceptibility to non-small cell lung cancer.International journal of cancer · 2007Article
- Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence.Radiation oncology (London, England) · 2007Article
- Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.Journal of neuro-oncology · 2007Article
- ATM and breast cancer susceptibility.Oncogene · 2006Review
- Article
- The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer.Human mutation · 2006Article
- ATM haplotypes and breast cancer risk in Jewish high-risk women.British journal of cancer · 2006Article
- Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.Breast cancer research : BCR · 2006Article
- Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.BMC cancer · 2005Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThe ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for mutations in the ATM gene are reported to have a fourfold to fivefold increased risk of breast cancer compared with noncarriers of the mutations, although not all studies have confirmed this association. Haplotype analysis has been suggested as an efficient method for investigating the role of common variation in the ATM gene and breast cancer. Five biallelic haplotype tagging single nucleotide polymorphisms are estimated to capture 99% of the haplotype diversity in Caucasian populations.
methodsWe conducted a nested case-control study of breast cancer within the Nurses' Health Study cohort to address the role of common ATM haplotypes and breast cancer. Cases and controls were genotyped for five haplotype tagging single nucleotide polymorphisms. Haplotypes were predicted for 1309 cases and 1761 controls for which genotype information was available.
resultsSix unique haplotypes were predicted in this study, five of which occur at a frequency of 5% or greater. The overall distribution of haplotypes was not significantly different between cases and controls (chi2 = 3.43, five degrees of freedom, P = 0.63).
conclusionThere was no evidence that common haplotypes of ATM are associated with breast cancer risk. Extensive single nucleotide polymorphism detection using the entire genomic sequence of ATM will be necessary to rule out less common variation in ATM and sporadic breast cancer risk.
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