ArticleGenes and immunity2004
Local adaptation and population differentiation at the interleukin 13 and interleukin 4 loci.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Identifying Genomic Signatures of Positive Selection to Predict Protective Genomic Loci in the Cohort of Lithuanian Clean-Up Workers of the Chornobyl Nuclear Disaster.Current issues in molecular biology · 2023Article
- Genetic signature of strong recent positive selection at interleukin-32 gene in goat.Asian-Australasian journal of animal sciences · 2017Article
- Positive selection of IL-33 in adaptive immunity of domestic Chinese goats.Ecology and evolution · 2017Article
- Article
- Crohn's disease and genetic hitchhiking at IBD5.Molecular biology and evolution · 2012Article
- Genome-wide scans for footprints of natural selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.The Journal of experimental medicine · 2009Article
- Linkage disequilibrium structure of the 5q31-33 region in a Thai population.Journal of human genetics · 2008Article
- Genetic variation and population structure of interleukin genes among seven ethnic populations from Karnataka, India.Journal of genetics · 2007Article
- ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population.Journal of human genetics · 2007Article
- Divergent patterns of linkage disequilibrium and haplotype structure across global populations at the interleukin-13 (IL13) locus.Genes and immunity · 2005Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
A 25.6 kb region at chromosome 5q31, covering the entire human interleukin 13 (IL-13) and interleukin 4 (IL-4) genes, has been reported to be associated with bronchial asthma. We have examined nucleotide variations at this locus in African, European American, and Japanese populations, using 120 diallelic variants. A block of strong linkage disequilibrium (LD) (mid R:D'mid R:>0.7) spans a 10 kb region containing IL-4 in European American and Japanese populations, and is present but less clear in African samples. Two major haplotypes at IL-4 account for >80% of haplotypes in European Americans and Japanese. These haplotypes are common and quite diverged from each other and the ancestral haplotype, resulting in highly significant deviations from neutrality. F(ST) statistics show that European American and Japanese populations are unusually distinct at the IL-4 locus. The most common haplotype in the European American population is much less common in the Japanese population, and vice versa. This implies that natural selection has acted on IL-4 haplotypes differently in different populations. This selected variation at IL-4 may account for some genetic variance underlying susceptibility to asthma and other allergic diseases. The strong LD observed in the IL-4 region may allow more efficient disease-association studies using this locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.