ArticleJournal of human hypertension2004
Endothelium and angiogenesis in white coat hypertension.
Article in Journal of human hypertension, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Metabolic syndrome and subchondral bone alterations: The rise of osteoarthritis - A review.Journal of clinical orthopaedics and trauma · 2020Article
- Ageing, obesity, dyslipidaemia, and hospital-room hypertension are clinical risk factors relating to pre-anaesthesia.Anaesthesiology intensive therapy · 2020Article
- The impact of protein oxidation on sustained and white coat hypertension.Anatolian journal of cardiology · 2017Observational
- Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1.Journal of human hypertension · 2015Article
- Closer look at white-coat hypertension.World journal of methodology · 2014Review
- Metabolic syndrome meets osteoarthritis.Nature reviews. Rheumatology · 2012Review
- Towards understanding the aetiology and pathophysiology of human hypertension: where are we now?Journal of human hypertension · 2006Article
- Insights into human hypertension: the role of endothelial dysfunction.Journal of human hypertension · 2006Article
- Endothelial progenitor cells in the vascular pathophysiology of hypertension: arterial stiffness, ageing and more.Journal of human hypertension · 2006Article
- Increased circulating concentrations of asymmetric dimethylarginine (ADMA) in white coat hypertension.Journal of human hypertension · 2005Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertensive patients are at particular risk of cardiovascular complications, possibly related to endothelial damage or dysfunction, or to abnormal angiogenesis. The aim of this study was to compare the risk conferred by white coat hypertension (WCH) vs sustained hypertension in the development of the endothelial dysfunction and abnormal angiogenesis by evaluating nitric oxide (NO=NO2+NO3), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and E-selectin levels in plasma. The study group included 102 subjects, 34 with WCH (17 male and 17 female patients) aged 49+/-11 years, 34 sustained hypertensives (HT) (15 male and 19 female patients) aged 47+/-11 years and 34 normotensive control subjects (NT) (16 male and 18 female patients) aged 48+/-10 years. WCH was defined as clinical hypertension and daytime ambulatory blood pressure less than 135/85 mmHg. The subjects were matched for age, gender, body mass index and the patients with smoking habit, dyslipidaemia, and diabetes mellitus were excluded from the study. The NO, ET-1, VEGF and E-selectin levels were analysed by ELISA technique. The WCH subjects had significantly higher levels of NO than the HT (41.68+/-2.23 vs 32.18+/-2.68 micromol/l; P<0.001) and significantly lower values than the NT (48.24+/-4.29 micromol/l; P<0.001). ET-1 levels of the WCH group were significantly higher than the NT (8.10+/-0.92 vs 5.95+/-0.26 ng/ml; P<0.001) and significantly lower than the HT (11.46+/-0.59 ng/ml; P<0.001). Considering with VEGF, the WCH group had significantly higher levels than the NT (195.88+/-11.84 vs 146.26+/-18.67 pg/ml; P<0.001), but the difference from the HT group was not significant (203.35+/-7.48 pg/ml; P=0.062). E-selectin in the WCH group was significantly lower than the HT (4.77+/-0.52 vs 8.49+/-2.85; P<0.001), but the difference from the NT group was not significant (3.86+/-0.67; P=0.077). Our data demonstrate that WCH is associated with endothelial dysfunction and abnormal angiogenesis. The degree of these changes is not as severe as observed in hypertensive population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.