ArticleProtein science : a publication of the Protein Society2004
Structural conservation in the major facilitator superfamily as revealed by comparative modeling.
Article in Protein science : a publication of the Protein Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 106 citations in OpenAlex.
- Structural basis of glucosinolate recognition and transport by plant GTR1.Cell discovery · 2026Article
- Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone.Communications biology · 2022Article
- Plant glucose transporter structure and function.Pflugers Archiv : European journal of physiology · 2020Review
- Engineering of Pentose Transport inFrontiers in bioengineering and biotechnology · 2019Review
- The ins and outs of vesicular monoamine transporters.The Journal of general physiology · 2018Review
- Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease.The European journal of neuroscience · 2017Review
- Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.The Biochemical journal · 2016Article
- Crystal structures of MdfA complexed with acetylcholine and inhibitor reserpine.Biophysics reports · 2016Article
- Aspergillus niger membrane-associated proteome analysis for the identification of glucose transporters.Biotechnology for biofuels · 2015Article
- Functionally important carboxyls in a bacterial homologue of the vesicular monoamine transporter (VMAT).The Journal of biological chemistry · 2014Article
- IcgA is a virulence factor of Rhodococcus equi that modulates intracellular growth.Infection and immunity · 2014Article
- Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression.The Journal of biological chemistry · 2013Article
- Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG.Molecular membrane biology · 2013Article
- Beginning to understand the role of sugar carriers in Colletotrichum lindemuthianum: the function of the gene mfs1.Journal of microbiology (Seoul, Korea) · 2013Article
- Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans.Genetics · 2012Article
- Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.The Journal of biological chemistry · 2012Article
- Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.Molecular pharmaceutics · 2012Article
- Spiroindolines identify the vesicular acetylcholine transporter as a novel target for insecticide action.PloS one · 2012Article
- Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3).American journal of physiology. Renal physiology · 2011Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The structures of membrane transporters are still mostly unsolved. Only recently, the first two high-resolution structures of transporters of the major facilitator superfamily (MFS) were published. Despite the low sequence similarity of the two proteins involved, lactose permease and glycerol-3-phosphate transporter, the reported structures are highly similar. This leads to the hypothesis that all members of the MFS share a similar structure, regardless of their low sequence identity. To test this hypothesis, we generated models of two other members of the MFS, the Tn10-encoded metal-tetracycline/H(+) antiporter (TetAB) and the rat vesicular monoamine transporter (rVMAT2). The models are based on the two MFS structures and on experimental data. The models for both proteins are in good agreement with the data available and support the notion of a shared fold for all MFS proteins.
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