ArticleNucleic acids research2004
SDPpred: a tool for prediction of amino acid residues that determine differences in functional specificity of homologous proteins.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Antimicrobial activities and phylogenetic study ofBiotechnologia · 2023Article
- Predicting the Specificity- Determining Positions of Receptor Tyrosine Kinase Axl.Frontiers in molecular biosciences · 2021Article
- Zebra2: advanced and easy-to-use web-server for bioinformatic analysis of subfamily-specific and conserved positions in diverse protein superfamilies.Nucleic acids research · 2020Article
- MAGA: A Supervised Method to Detect Motifs From Annotated Groups in Alignments.Evolutionary bioinformatics online · 2020Article
- Si permeability of a deficient Lsi1 aquaporin in tobacco can be enhanced through a conserved residue substitution.Plant direct · 2019Article
- An Uncharacterized Member of the Gls24 Protein Superfamily Is a Putative Sensor of Essential Amino Acid Availability in Streptococcus pneumoniae.Microbial ecology · 2019Article
- Chimeric Structure of Plant Malic Enzyme Family: Different Evolutionary Scenarios for NAD- and NADP-Dependent Isoforms.Frontiers in plant science · 2018Article
- Molecular Evolution and Functional Divergence of the IgLON Family.Evolutionary bioinformatics online · 2018Article
- Article
- Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses.Molecular biology and evolution · 2015Article
- Molecular evolution of the enzymes involved in the sphingolipid metabolism of Leishmania: selection pressure in relation to functional divergence and conservation.BMC evolutionary biology · 2014Article
- Prediction of detailed enzyme functions and identification of specificity determining residues by random forests.PloS one · 2014Article
- SigniSite: Identification of residue-level genotype-phenotype correlations in protein multiple sequence alignments.Nucleic acids research · 2013Article
- Janus: prediction and ranking of mutations required for functional interconversion of enzymes.Journal of molecular biology · 2013Article
- Article
- Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.Nucleic acids research · 2012Article
- SPEER-SERVER: a web server for prediction of protein specificity determining sites.Nucleic acids research · 2012Article
- Article
- Predicting the functional impact of protein mutations: application to cancer genomics.Nucleic acids research · 2011Article
- WRKY gene family evolution in Arabidopsis thaliana.Genetica · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SDPpred (Specificity Determining Position prediction) is a tool for prediction of residues in protein sequences that determine the proteins' functional specificity. It is designed for analysis of protein families whose members have biochemically similar but not identical interaction partners (e.g. different substrates for a family of transporters). SDPpred predicts residues that could be responsible for the proteins' choice of their correct interaction partners. The input of SDPpred is a multiple alignment of a protein family divided into a number of specificity groups, within which the interaction partner is believed to be the same. SDPpred does not require information about the secondary or three-dimensional structure of proteins. It produces a set of the alignment positions (specificity determining positions) that determine differences in functional specificity. SDPpred is available at http://math.genebee.msu.ru/~psn/.
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