ArticleMolecular biology of the cell2004
Arrival, reversal, and departure of neurofilaments at the tips of growing axons.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Gαi2 promotes microtubule-driven incorporation of neurofilaments to stabilise nascent axons in vivo.EMBO reports · 2026Article
- Nestin Selectively Facilitates the Phosphorylation of the Lissencephaly-Linked Protein Doublecortin (DCX) by cdk5/p35 to Regulate Growth Cone Morphology and Sema3a Sensitivity in Developing Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A mechanism for neurofilament transport acceleration through nodes of Ranvier.Molecular biology of the cell · 2020Article
- Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?Frontiers in cellular neuroscience · 2020Article
- Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid.Journal of proteomics · 2019Article
- Local Acceleration of Neurofilament Transport at Nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Axonal neurofilaments exhibit frequent and complex folding behaviors.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Kymograph analysis with high temporal resolution reveals new features of neurofilament transport kinetics.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Local regulation of neurofilament transport by myelinating cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Severing and end-to-end annealing of neurofilaments in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- How does the motor relearning program improve neurological function of brain ischemia monkeys?Neural regeneration research · 2013Article
- A critical reevaluation of the stationary axonal cytoskeleton hypothesis.Cytoskeleton (Hoboken, N.J.) · 2013Review
- FluoroMyelin™ Red is a bright, photostable and non-toxic fluorescent stain for live imaging of myelin.Journal of neuroscience methods · 2012Article
- Neurofilaments are flexible polymers that often fold and unfold, but they move in a fully extended configuration.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Axonal transport of neurofilaments: a single population of intermittently moving polymers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport.Molecular neurodegeneration · 2010Article
- Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments.Molecular biology of the cell · 2009Article
- Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging.Aging cell · 2009Article
- Neurofilaments switch between distinct mobile and stationary states during their transport along axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the movement of green fluorescent protein-tagged neurofilaments at the distal ends of growing axons by using time-lapse fluorescence imaging. The filaments moved in a rapid, infrequent, and asynchronous manner in either an anterograde or retrograde direction (60% anterograde, 40% retrograde). Most of the anterograde filaments entered the growth cone and most of the retrograde filaments originated in the growth cone. In a small number of cases we were able to observe neurofilaments reverse direction, and all of these reversals occurred in or close to the growth cone. We conclude that neurofilament polymers are delivered rapidly and infrequently to the tips of growing axons and that some of these polymers reverse direction in the growth cone and move back into the axon. We propose that 1) growth cones are a preferential site of neurofilament reversal in distal axons, 2) most retrograde neurofilaments in distal axons originate by reversal of anterograde filaments in the growth cone, 3) those anterograde filaments that do not reverse direction are recruited to form the neurofilament cytoskeleton of the newly forming axon, and 4) the net delivery of neurofilament polymers to growth cones may be controlled by regulating the reversal frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.