ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Control of roof plate development and signaling by Lmx1b in the caudal vertebrate CNS.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07281638 (Bedside Bike Early Mobilization Program for Inpatients), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bedside Bike Early Mobilization Program for Inpatients
Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- Dual repression modes triggered by constitutively stabilized beta-catenin in the dorsal neural tube underlie cell fate alterations of the roof plate, neural crest, and dorsal interneurons.Cell & bioscience · 2026Article
- Early spinal cord development: from neural tube formation to neurogenesis.Nature reviews. Neuroscience · 2025Review
- Article
- Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates.Development (Cambridge, England) · 2024Article
- A long noncoding RNA cluster-based genomic locus maintains proper development and visual function.Nucleic acids research · 2019Article
- Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tube.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons.Neural development · 2016Article
- Dynamics of BMP and Hes1/Hairy1 signaling in the dorsal neural tube underlies the transition from neural crest to definitive roof plate.BMC biology · 2016Article
- Changing Faces of Transcriptional Regulation Reflected by Zic3.Current genomics · 2015Article
- Expression of Nemo-like kinase after spinal cord injury in rats.Journal of molecular neuroscience : MN · 2014Article
- Detailed expression analysis of regulatory genes in the early developing human neural tube.Stem cells and development · 2014Article
- Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development.Biology open · 2013Article
- Hand in glove: brain and skull in development and dysmorphogenesis.Acta neuropathologica · 2013Review
- A novel role for FOXA2 and SHH in organizing midbrain signaling centers.Developmental biology · 2012Article
- Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.Development (Cambridge, England) · 2011Article
- Identification of cerebellin2 in chick and its preferential expression by subsets of developing sensory neurons and their targets in the dorsal horn.The Journal of comparative neurology · 2010Article
- Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Article
- Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.Cell and tissue research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have identified the roof plate as an important signaling center controlling dorsal interneuron specification and differentiation in the developing spinal cord. Currently, the molecular pathways of roof plate formation and function are poorly understood. We determined that the LIM-homeodomain transcription factor Lmx1b is sufficient to induce functional roof plate in the early chick developing spinal cord. In the chick, Lmx1b acts upstream of Lmx1a in the roof plate developmental program. Once the roof plate forms, we show that Bmp and Wnt signaling are the major components of Lmx1a/b-dependent roof plate dorsal patterning activity. The roof plate function of Lmx1b is not conserved across vertebrates because Lmx1b is not expressed in mouse roof plate progenitors. Instead, mouse caudal CNS roof plate formation relies entirely on Lmx1a. Lmx1b can, however, partially rescue roof plate development in dreher (Lmx1a-/-) mice, indicating that Lmx1b has some functional redundancy to Lmx1a. Furthermore, we demonstrate that the roof plate-inducing activity of Lmx1b can be suppressed by Mash1 (Cash1), which is normally expressed in intermediate neural tube in both chick and mouse. Our data identify Lmx1b as a key regulator of spinal cord roof plate induction and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.