ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascade.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Restoration of Saccadic Eye Movements and Visually Guided Behavior in Ambient White Light with Photoswitchable Small Molecules.Journal of the American Chemical Society · 2026Article
- The Bovine Ex Vivo Retina: A Versatile Model for Retinal Neuroscience.Investigative ophthalmology & visual science · 2023Article
- Differential epitope masking reveals synapse-specific complexes of TRPM1.Visual neuroscience · 2018Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.The European journal of neuroscience · 2016Article
- The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina.Investigative ophthalmology & visual science · 2015Article
- Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool.PLoS biology · 2015Article
- RGS Protein Regulation of Phototransduction.Progress in molecular biology and translational science · 2015Review
- G protein signaling in the retina and beyond: the Cogan lecture.Investigative ophthalmology & visual science · 2014Article
- Kir2.4 surface expression and basal current are affected by heterotrimeric G-proteins.The Journal of biological chemistry · 2013Article
- Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Metabotropic glutamate receptors: from the workbench to the bedside.Neuropharmacology · 2011Review
- Nonlinearity and noise at the rod-rod bipolar cell synapse.Visual neuroscience · 2011Article
- PKC{alpha} is essential for the proper activation and termination of rod bipolar cell response.Investigative ophthalmology & visual science · 2010Article
- Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.The Journal of biological chemistry · 2010Article
- Functional redundancy of R7 RGS proteins in ON-bipolar cell dendrites.Investigative ophthalmology & visual science · 2010Article
- Mutations in TRPM1 are a common cause of complete congenital stationary night blindness.American journal of human genetics · 2009Article
- Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans.American journal of human genetics · 2009Article
- Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
G(o) is the most abundant G-protein in the brain, but its regulators are essentially unknown. In retina, Galpha(o1) is obligatory in mediating the metabotropic glutamate receptor 6 (mGluR6)-initiated ON response. To identify the interactors of G(o), we conducted a yeast two-hybrid screen with constituitively active Galpha(o) as a bait. The screen frequently identified a regulator of G-protein signaling (RGS), Ret-RGS1, the interaction of which we confirmed by coimmunoprecipitation with Galpha(o) in transfected cells and in retina. Ret-RGS1 localized to the dendritic tips of ON bipolar neurons, along with mGluR6 and Galpha(o1). When Ret-RGS1 was coexpressed in Xenopus oocytes with mGluR6, Galpha(o1), and a GIRK (G-protein-gated inwardly rectifying K+) channel, it accelerated the deactivation of the channel response to glutamate in a concentration-dependent manner. Because light onset suppresses glutamate release from photoreceptors onto the ON bipolar dendrites, Ret-RGS1 should accelerate the rising phase of the light response of the ON bipolar cell. This would tend to match its kinetics to that of the OFF bipolar that arises directly from ligand-gated channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.