ArticleAntimicrobial agents and chemotherapy2004
Constitutive activation of the PDR16 promoter in a Candida albicans azole-resistant clinical isolate overexpressing CDR1 and CDR2.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Phenotypic Switching and Filamentation in Candida haemulonii, an Emerging Opportunistic Pathogen of Humans.Microbiology spectrum · 2021Article
- Transcriptional profiling of azole-resistant Candida parapsilosis strains.Antimicrobial agents and chemotherapy · 2011Article
- Regulation of the hypoxic response in Candida albicans.Eukaryotic cell · 2010Article
- Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.Eukaryotic cell · 2009Article
- Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance.Eukaryotic cell · 2008Article
- Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.Eukaryotic cell · 2007Article
- Article
- Cellular and molecular biology of Candida albicans estrogen response.Eukaryotic cell · 2006Article
- cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol.Antimicrobial agents and chemotherapy · 2005Article
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Authors and funding
2 authors.
Funding
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Abstract
Candida albicans azole-resistant clinical isolates overexpressing the CDR1 and CDR2 genes (multidrug transporters) also overexpress the PDR16 gene (phosphatidylinositol transfer protein). We show here that the PDR16 promoter displays higher transcriptional activity following integration in an azole-resistant isolate than in the matched azole-susceptible one. Thus, the upregulation of PDR16 in the resistant strain results from a mutation acting in trans.
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