ArticleAntimicrobial agents and chemotherapy2004
Antibiotic resistance conferred by a class I integron and SXT constin in Vibrio cholerae O1 strains isolated in Laos.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 125 citations in OpenAlex.
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- Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.Microbiology spectrum · 2023Article
- Spectrum of ctxB genotypes, antibiogram profiles and virulence genes of Vibrio cholerae serogroups isolated from environmental water sources from Odisha, India.BMC microbiology · 2023Article
- Clinical and Environmental Vibrio cholerae Non-O1, Non-O139 Strains from Australia Have Similar Virulence and Antimicrobial Resistance Gene Profiles.Microbiology spectrum · 2023Article
- Distribution and Molecular Characteristics ofMicroorganisms · 2022Article
- Azithromycin can induce SOS response and horizontal gene transfer of SXT element in Vibrio cholerae.Molecular biology reports · 2022Article
- VicPred: AFrontiers in microbiology · 2021Article
- Geographical distribution and antibiotics susceptibility patterns of toxigenic Vibrio cholerae isolates from Kisumu County, Kenya.African journal of primary health care & family medicine · 2020Article
- Molecular Analysis of Selected Resistance Determinants in Diarrheal Fecal Samples Collected From Kolkata, India Reveals an Abundance of Resistance Genes and the Potential Role of the Microbiota in Its Dissemination.Frontiers in public health · 2020Article
- Altered Integrative and Conjugative Elements (ICEs) in RecentFrontiers in microbiology · 2019Article
- Integrative and Conjugative Elements-PositiveFrontiers in microbiology · 2019Article
- Integrative and conjugative elements and their hosts: composition, distribution and organization.Nucleic acids research · 2017Article
- Killing of Serratia marcescens biofilms with chloramphenicol.Annals of clinical microbiology and antimicrobials · 2017Article
- Identification and analysis of integrons and cassette arrays in bacterial genomes.Nucleic acids research · 2016Article
- Antimicrobial Susceptibility of Autochthonous AquaticFrontiers in microbiology · 2016Article
- Emergence of Tetracycline Resistant Vibrio cholerae O1 Biotype El Tor Serotype Ogawa with Classical ctxB Gene from a Cholera Outbreak in Odisha, Eastern India.Journal of pathogens · 2016Article
- The mosaic accessory gene structures of the SXT/R391-like integrative and conjugative elements derived from Vibrio spp. isolated from aquatic products and environment in the Yangtze River Estuary, China.BMC microbiology · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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Abstract
Changes in the drug susceptibility pattern were observed in Vibrio cholerae O1 isolated in the Lao People's Democratic Republic during 1993 to 2000. In this study, 50 V. cholerae O1 strains were selected during this period for studying the presence of class I integron and SXT constin. Twenty-four streptomycin-resistant strains out of 26 isolated before 1997 contained a class I integron harboring the aadA1 gene cassette. Twenty-four strains isolated after 1997 contained an SXT constin (a large conjugative element). Twenty of the strains were resistant to chloramphenicol, tetracycline, streptomycin, and trimethoprim-sulfamethoxazole, while four strains were susceptible to the antibiotic tested. The resistance genes included in the SXT constins were floR, tetA, strAB, and sulII, which encode resistance to chloramphenicol, tetracycline, streptomycin, and sulfamethoxazole, respectively. The antibiotic resistance gene cluster was found to be deleted in the four susceptible strains. SXT(LAOS) did not contain dfrA1 or dfr18, which confer resistance to trimethoprim in SXT(ET) and SXT(MO10), respectively. A hot spot region of SXT(LAOS) was sequenced, and we identified two novel open reading frames showing homology to sO24 (exonuclease) and sO23 (helicase) of the genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104. Analysis of SXT(LAOS) showed that there is a continuous flux of genes among V. cholerae SXT constins which should be carefully monitored.
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