ArticleMetabolic brain disease2004
Biochemical model for inflammation of the brain: the effect of iron and transferrin on monocytes and lipid peroxidation.
Article in Metabolic brain disease, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions.PloS one · 2019Article
- Patient stratification in clinical glaucoma trials using the individual tear proteome.Scientific reports · 2018Article
- Magnetic resonance imaging evidence of hippocampal structural changes in patients with primary biliary cholangitis.Clinical and translational gastroenterology · 2018Article
- Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage.Pathophysiology : the official journal of the International Society for Pathophysiology · 2017Article
- The conundrum of iron in multiple sclerosis--time for an individualised approach.Metabolic brain disease · 2012Review
- Ceruloplasmin/Transferrin ratio changes in Alzheimer's disease.International journal of Alzheimer's disease · 2010Article
- Genetic variants of transferrin in cystic fibrosis.Journal of inherited metabolic disease · 2008Article
- Lack of clinical manifestation of hereditary haemochromatosis in South African patients with multiple sclerosis.Metabolic brain disease · 2006Article
- Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis.Metabolic brain disease · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral inflammation plays a role in diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), and depression. Iron is involved in infection and inflammation through free radical production. Theoretically transferrin should prohibit iron from participating in oxidative reactions, but transferrin has also been found to promote free radical damage. We reported previously that isolation of transferrin from plasma by ion exchange column chromatography produced a broad pink protein band that subsequently separated on a gel filtration column into three proteins containing many metals. In this study some properties of the three proteins were studied in 20 volunteers. Protein 3 (identified as transferrin by nephelometry) contained the most iron while Protein 1 (called "toxiferrin") contained significantly less iron (p < 0.00001). Plasma from volunteers obtained under conditions of infection/inflammation with fever (n = 5) had a significantly increased toxiferrin to transferrin ratio compared to healthy volunteers (n = 15; p < 0.001). In vitro, Protein 2 and transferrin inhibited lipid peroxidation, while toxiferrin (possibly a protease degradation product of transferrin), enhanced lipid peroxidation. Also, toxiferrin (1 mg/mL) caused a significant increase in viability of monocytes as measured by the 3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyl tetrazolium bromide (MTT) reduction test, as well as the morphological transformation of monocytes to macrophages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.