ArticleAnnals of surgery2004
Bone marrow norepinephrine mediates development of functionally different macrophages after thermal injury and sepsis.
Article in Annals of surgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Neuroimmune Interactions and Their Role in Immune Cell Trafficking in Cardiovascular Diseases and Cancer.International journal of molecular sciences · 2025Review
- The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.American journal of respiratory and critical care medicine · 2018Observational
- Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.Current opinion in hematology · 2018Review
- The immune system's role in sepsis progression, resolution, and long-term outcome.Immunological reviews · 2016Review
- Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4.PloS one · 2015Article
- Is It Time to Beta Block the Septic Patient?BioMed research international · 2015Review
- Neuroendocrine regulation of inflammation.Seminars in immunology · 2014Review
- Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Do all β-blockers attenuate the excess hematopoietic progenitor cell mobilization from the bone marrow following trauma/hemorrhagic shock?The journal of trauma and acute care surgery · 2014Article
- Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Molecular pathways: beta-adrenergic signaling in cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Review
- Burn injury dampens erythroid cell production through reprioritizing bone marrow hematopoietic response.The Journal of trauma · 2011Article
- Inhibition of multidrug-resistant Acinetobacter baumannii by nonviral expression of hCAP-18 in a bioengineered human skin tissue.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
- Bench-to-bedside review: Beta-adrenergic modulation in sepsis.Critical care (London, England) · 2009Review
- Murine hematopoietic stem cells and progenitors express adrenergic receptors.Journal of neuroimmunology · 2007Article
- Propranolol restores the tumor necrosis factor-alpha response of circulating inflammatory monocytes and granulocytes after burn injury and sepsis.Journal of burn care & research : official publication of the American Burn AssociationArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe sought to determine the influence of thermal (burn) injury with sepsis and norepinephrine on the clonogenic potential and functional cytokine response to lipopolysaccharide (LPS) stimulation in nonmyeloid committed (CD117) and myeloid committed (ER-MP12) bone marrow progenitor cells. SUMMARY AND BACKGROUND DATA: We have previously demonstrated that norepinephrine stimulated myelopoiesis after burn injury and sepsis, but the site of this stimulation in monocyte development is unknown. In the present study the influence of norepinephrine on the developmental hierarchy of bone marrow cells after thermal injury and sepsis was determined by assessing the clonogenic potential and LPS-stimulated cytokine responses of mature macrophages derived from CD117 and ER-MP12 bone marrow progenitor cells.
methodsTissue and bone marrow norepinephrine content was ablated by chemical sympathectomy with 6-hydroxydopamine treatment. CD117 and ER-MP12 bone marrow cells were isolated using antibody-linked magnetic microbeads. Clonogenic potential in response to colony-stimulating factors was determined. Both progenitor cell types were differentiated to mature macrophages in vitro and tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 cytokine responses to LPS provocation were determined.
resultsThe macrophage- and granulocyte-macrophage colony-stimulating factor responsive clonogenic potential was increased with burn sepsis, suggesting an expansion of both progenitor populations. Such increases were greatly reduced with prior depletion of norepinephrine. TNF-alpha and IL-6 cytokine responses to LPS were markedly influenced by the specific progenitor cells involved as well as the injury conditions and the status of norepinephrine prior to injury. In burn sepsis the depletion of norepinephrine resulted in a dramatic decrease in both IL-6 and TNF-alpha production by both progenitor-derived macrophages.
conclusionsDepletion of norepinephrine attenuated burn and burn sepsis-induced bone marrow progenitor clonal growth in response to macrophage- and granulocyte-macrophage colony-stimulating factor. Functional phenotypes of bone marrow progenitor-derived macrophages are greatly influenced by norepinephrine and the milieu created by thermal injury and sepsis.
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