ArticleInfection and immunity2004
Protection afforded by heat shock protein 60 from Francisella tularensis is due to copurified lipopolysaccharide.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- GrpE Immunization Protects AgainstFrontiers in immunology · 2020Article
- An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia.Journal of immunology research · 2018Article
- Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles.PloS one · 2018Article
- Further Characterization of the Capsule-Like Complex (CLC) Produced byFrontiers in cellular and infection microbiology · 2018Article
- B-cell epitopes in GroEL of Francisella tularensis.PloS one · 2014Article
- A mucosal subunit vaccine protects against lethal respiratory infection with Francisella tularensis LVS.PloS one · 2012Article
- Immunoreactive Coxiella burnetii Nine Mile proteins separated by 2D electrophoresis and identified by tandem mass spectrometry.Microbiology (Reading, England) · 2011Article
- Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia.PloS one · 2010Article
- Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells.BMC microbiology · 2008Article
- Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia.Clinical and vaccine immunology : CVI · 2008Article
- Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.Immunology letters · 2007Article
- The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens.Infection and immunity · 2007Article
- Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins (Hsps) have attracted significant attention as protective antigens against a range of diseases caused by bacterial pathogens. However, more recently there have been suggestions that the protective response is due to the presence of peptide components other than Hsps. We have shown that mice that had been immunized with purified heat shock protein 60 (Hsp60) isolated from Francisella tularensis were protected against a subsequent challenge with some strains of the bacterium. However, this protection appeared to be due to trace amounts of lipopolysaccharide, which were too low to be detected by using the Limulus amoebocyte lysate assay. This finding raises the possibility that the protection afforded by other bacterial Hsp60 proteins may be due to trace quantities of polysaccharide antigens carried by and acting in conjunction with the Hsps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.