Trial reportThe American journal of clinical nutrition2004
Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women.
Trial report in The American journal of clinical nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Regulation of Bone - Aim 3
Nutritional Regulation of Bone - Pilot Study
Nutritional Regulation of Bone - Aim 1
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Calcium supplementation for people with overweight or obesity.The Cochrane database of systematic reviews · 2024Pooled it
- Does exercise affect bone mineral density and content when added to a calorie-restricted diet? A systematic review and meta-analysis of controlled clinical trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- [Austrian guidance for the pharmacological treatment of osteoporosis in postmenopausal women--update 2009].Wiener medizinische Wochenschrift. Supplement · 2009Guideline
- Canadian Consensus Conference on osteoporosis, 2006 update.Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2006Guideline
- Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Trial
- Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Trial
- Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial.The American journal of clinical nutrition · 2013Trial
- Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women.European journal of clinical nutrition · 2012Trial
- Areal and volumetric bone mineral density and geometry at two levels of protein intake during caloric restriction: a randomized, controlled trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Trial
- Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women.European journal of clinical nutrition · 2010Trial
- Comparison of the absorption of calcium carbonate and calcium citrate after Roux-en-Y gastric bypass.Obesity surgery · 2009Trial
- Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake.The American journal of clinical nutrition · 2007Trial
- Overweight postmenopausal women lose bone with moderate weight reduction and 1 g/day calcium intake.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005Trial
- Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026Review
- Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status.The Journal of clinical endocrinology and metabolism · 2023Observational
- Fracture Risk in Vegetarians and Vegans: the Role of Diet and Metabolic Factors.Current osteoporosis reports · 2022Review
- Treatment of Diabetes and Osteoporosis-A Reciprocal Risk?Biomedicines · 2022Review
- Changes in Bone Mineral Density After Weight Loss Due to Metabolic Surgery or Lifestyle Intervention in Obese Patients.Obesity surgery · 2021Article
- Molecular and Lifestyle Factors Modulating Obesity Disease.Biomedicines · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWeight loss (WL) reduces bone mass and increases fracture risk. Mechanisms regulating calcium metabolism during WL are unclear.
objectiveThe objective was to assess the effect of 6 wk of WL at 2 different amounts of calcium intake [normal (NlCa): 1 g/d; high (HiCa): 1.8 g/d] on true fractional calcium absorption (TFCA), bone turnover, and bone-regulating hormones in overweight postmenopausal women.
designSeventy-three women (body mass index, 26.9 +/- 1.9 kg/m(2)) were recruited either to consume a moderately energy-restricted diet (WL group) or to maintain their body weight [weight-maintenance (WM) group] and were randomly assigned to either the HiCa or the NlCa group in a double-blind manner. Subjects underwent weekly diet counseling, and measurements were taken at baseline and after 6 wk.
resultsFifty-seven women completed the study and had a baseline TFCA of 24.9 +/- 7.4%. Energy restriction significantly decreased the total calcium absorbed (P < 0.05) in the WL group (n = 32) compared with the WM group (n = 25; analysis of covariance). Regression analysis showed that a greater rate of weight loss suppressed TFCA and the total calcium absorbed (P < 0.05) in the HiCa group. The women in the NlCa WL group absorbed inadequate amounts of calcium (195 +/- 49 mg/d), whereas the women in the HiCa WL group absorbed adequate amounts (348 +/- 118 mg/d). Parathyroid hormone explained 22% of the variance in calcium absorbed in the NlCa group only.
conclusionsWe suggest that WL is associated with elevated calcium requirements that, if not met, could activate the calcium-parathyroid hormone axis to absorb more calcium. Normal intakes of calcium during energy restriction result in inadequate total calcium absorption and could ultimately compromise calcium balance and bone mass.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.